{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:39:00Z","timestamp":1779262740492,"version":"3.51.4"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"unspecified","delay-in-days":228,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Symptoms are currently used as testing indicators for SARS-CoV-2 in England. In this study, we analysed national contact tracing data for England (NHS Test and Trace) for the period 1 December to 28 December 2021 to explore symptom differences between the variants, Delta and Omicron. We found that at least one of the symptoms currently used as indicators (fever, cough and loss of smell and taste) were reported in 61.5% of Omicron cases and 72.2% in Delta cases, suggesting that these symptoms are less predictive of Omicron infections. Nearly 40% of Omicron infections did not report any of the three key indicative symptoms, reinforcing the importance of the entire spectrum of symptoms for targeted testing. After adjusting for potential confounding factors, fever and cough were more commonly associated with Omicron infections compared to Delta, showing the importance of considering age and vaccination status when assessing symptom profiles. Sore throat was also more commonly reported in Omicron infections, and loss of smell and taste more commonly reported in Delta infections. Our study shows the value of continued monitoring of symptoms associated with SARS-CoV-2, as changes may influence the effectiveness of testing policy and case ascertainment approaches.<\/jats:p>","DOI":"10.1017\/s0950268822001297","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T07:16:06Z","timestamp":1660720566000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":21,"title":["Comparative symptomatology of infection with SARS-CoV-2 variants Omicron (B.1.1.529) and Delta (B.1.617.2) from routine contact tracing data in England"],"prefix":"10.1017","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8565-6740","authenticated-orcid":false,"given":"Alice K. E.","family":"Ekroth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Patrzylas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlie","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3781-0117","authenticated-orcid":false,"given":"Gareth J.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"S0950268822001297_ref12","unstructured":"12. COVID-19 vaccine surveillance report. Available at https:\/\/www.gov.uk\/government\/publications\/covid-19-vaccine-weekly-surveillance-reports (Accessed 18 March 2022)."},{"key":"S0950268822001297_ref10","doi-asserted-by":"publisher","DOI":"10.1101\/2022.01.18.22269082"},{"key":"S0950268822001297_ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.00473"},{"key":"S0950268822001297_ref16","unstructured":"16. Bentley, EG (2021) SARS-CoV-2 Omicron-B.1.1.529 variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19. bioRxiv. doi: 2021.2012.2026.474085"},{"key":"S0950268822001297_ref18","doi-asserted-by":"crossref","unstructured":"18. Abdelnabi, R (2021) The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamsters. bioRxiv. doi: 2021.2012.2024.474086","DOI":"10.1101\/2021.12.24.474086"},{"key":"S0950268822001297_ref15","unstructured":"15. UKHSA (2022) Weekly national Influenza and COVID-19 surveillance report. Week 2 report (up to week 1 data). 13 January 2022. Available at: https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/1046284\/weekly-flu-and-covid-19-report-week-2-2022.pdf. (Accessed 18 March 2022)."},{"key":"S0950268822001297_ref4","unstructured":"4. UKHSA (2022) SARS-CoV-2 variants of concern and variants under investigation in England. Technical Briefing 34. Available at https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/1050236\/technical-briefing-34-14-january-2022.pdf (Accessed 18 March 2022)."},{"key":"S0950268822001297_ref13","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s15010-021-01599-5","article-title":"COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study","volume":"49","author":"Abdukahil","year":"2021","journal-title":"Infection"},{"key":"S0950268822001297_ref8","unstructured":"8. ZOE: Omicron and cold-like symptoms rapidly taking over in London. Available at https:\/\/covid.joinzoe.com\/post\/omicron-and-cold-like-symptoms-rapidly-taking-over-in-london (Accessed 18 January 2022)."},{"key":"S0950268822001297_ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18963-y"},{"key":"S0950268822001297_ref3","unstructured":"3. Scientific Pandemic Influenza Group on Modelling: Consensus Statement on COVID-19. Available at https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/993321\/S1267_SPI-M-O_Consensus_Statement.pdf (Accessed 14 February 2022)."},{"key":"S0950268822001297_ref9","unstructured":"9. ZOE: What are the new top 5 COVID symptoms?. Available at https:\/\/covid.joinzoe.com\/post\/new-top-5-covid-symptoms (Accessed 18 January 2022)."},{"key":"S0950268822001297_ref1","unstructured":"1. Rambaut, A (2020) Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations. Available at: https:\/\/virological.org\/t\/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations\/563 (Accessed 18 March 2022)."},{"key":"S0950268822001297_ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04479-6"},{"key":"S0950268822001297_ref2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg3055"},{"key":"S0950268822001297_ref11","doi-asserted-by":"publisher","DOI":"10.1101\/2021.09.14.21263578"},{"key":"S0950268822001297_ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0916-2"},{"key":"S0950268822001297_ref7","doi-asserted-by":"publisher","DOI":"10.1101\/2021.08.19.21262231"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268822001297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T08:08:23Z","timestamp":1663142903000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268822001297\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":18,"alternative-id":["S0950268822001297"],"URL":"https:\/\/doi.org\/10.1017\/s0950268822001297","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2022. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e162"}}