{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T04:08:11Z","timestamp":1769314091206,"version":"3.49.0"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"unspecified","delay-in-days":51,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>The association between time to positivity (TTP) of blood culture and the clinical prognosis of patients with <jats:italic>Klebsiella pneumoniae<\/jats:italic> bloodstream infection (BSI) remains unclear. A retrospective study of 148 inpatients with BSI caused by <jats:italic>K. pneumoniae<\/jats:italic> was performed at Shanghai Tongji Hospital, China, from October 2016\u20132020. The total in-hospital fatality rate was 32%. The median TTP was 11.0 (7.7\u201316.1) h and the optimal cutoff for prediction of in-hospital mortality was 9.4 h according to the ROC curve. Early TTP (&lt;9.4 h) was a risk factor for in-hospital mortality by univariate analysis (OR = 2.5, 95% CI 1.2\u20135.0, <jats:italic>P<\/jats:italic> = 0.01), but not by multivariate analysis (OR = 2.7, 95% CI 1.0\u20137.4, <jats:italic>P<\/jats:italic> = 0.06). Old age, serum creatinine, white blood cells, and C-reactive protein values were risk factors for in-hospital mortality by multivariate analysis. Early TTP was not a risk factor for septic shock (OR = 1.8, 95% CI 0.6\u20135.1, <jats:italic>P<\/jats:italic> = 0.27) or ICU admission (OR = 1.0, 95% CI 1.0\u20131.0, <jats:italic>P<\/jats:italic> = 0.32). In conclusion, the in-hospital fatality rate of patients with <jats:italic>K. pneumoniae<\/jats:italic> BSI was relatively high and associated with an early TTP of blood cultures. However, no increased risk of mortality, septic shock or ICU admission was evident in early TTP patients.<\/jats:p>","DOI":"10.1017\/s0950268823000262","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T11:43:24Z","timestamp":1676979804000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Is early time to positivity of blood culture associated with clinical prognosis in patients with <i>Klebsiella pneumoniae<\/i> bloodstream infection?"],"prefix":"10.1017","volume":"151","author":[{"given":"Weiwei","family":"Hou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantian","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangbo","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5779-1817","authenticated-orcid":false,"given":"Yan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"S0950268823000262_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011796"},{"key":"S0950268823000262_ref15","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1617687"},{"key":"S0950268823000262_ref2","doi-asserted-by":"publisher","DOI":"10.5588\/pha.21.0044"},{"key":"S0950268823000262_ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0289"},{"key":"S0950268823000262_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-016-2727-4"},{"key":"S0950268823000262_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-016-2580-5"},{"key":"S0950268823000262_ref7","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2012.678883"},{"key":"S0950268823000262_ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-05257-3"},{"key":"S0950268823000262_ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07098-8"},{"key":"S0950268823000262_ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208819"},{"key":"S0950268823000262_ref18","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2019-001185"},{"key":"S0950268823000262_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.05.043"},{"key":"S0950268823000262_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2016.07.002"},{"key":"S0950268823000262_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.07.015"},{"key":"S0950268823000262_ref1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.11532.1"},{"key":"S0950268823000262_ref9","first-page":"638","article-title":"Time to positivity of blood cultures in patients with bloodstream infections: a useful prognostic tool","volume":"35","author":"Mart\u00edn-Guti\u00e9rrez","year":"2017","journal-title":"Enfermedades Infecciosas Microbiologia Clinica"},{"key":"S0950268823000262_ref20","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab321"},{"key":"S0950268823000262_ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-017-0191-3"},{"key":"S0950268823000262_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02720.x"},{"key":"S0950268823000262_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2021.115396"},{"key":"S0950268823000262_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03675-8"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268823000262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T11:02:13Z","timestamp":1679050933000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268823000262\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":21,"alternative-id":["S0950268823000262"],"URL":"https:\/\/doi.org\/10.1017\/s0950268823000262","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e43"}}