{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T14:24:38Z","timestamp":1782224678483,"version":"3.54.5"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"unspecified","delay-in-days":142,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8200082669"],"award-info":[{"award-number":["8200082669"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Burn patients are at high risk of central line\u2013associated bloodstream infection (CLABSI). However, the diagnosis of such infections is complex, resource-intensive, and often delayed. This study aimed to investigate the epidemiology of CLABSI and develop a prediction model for the infection in burn patients. The study analysed the infection profiles, clinical epidemiology, and central venous catheter (CVC) management of patients in a large burn centre in China from January 2018 to December 2021. In total, 222 burn patients with a cumulative 630 CVCs and 5,431 line-days were included. The CLABSI rate was 23.02 CVCs per 1000 line-days. The three most common bacterial species were <jats:italic>Acinetobacter baumannii, Staphylococcus aureus<\/jats:italic>, and <jats:italic>Pseudomonas aeruginosa<\/jats:italic>; 76.09% of isolates were multidrug resistant. Compared with a non-CLABSI cohort, CLABSI patients were significantly older, with more severe burns, more CVC insertion times, and longer total line-days, as well as higher mortality. Regression analysis found longer line-days, more catheterisation times, and higher burn wounds index to be independent risk factors for CLABSI. A novel nomogram based on three risk factors was constructed with an area under the receiver operating characteristic curve (AUROC) value of 0.84 (95% CI: 0.782\u20130.898) with a mean absolute error of calibration curve of 0.023. The nomogram showed excellent predictive ability and clinical applicability, and provided a simple, practical, and quantitative strategy to predict CLABSI in burn patients.<\/jats:p>","DOI":"10.1017\/s0950268823000766","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T06:54:30Z","timestamp":1684824870000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Clinical epidemiology and a novel predicting nomogram of central line associated bloodstream infection in burn patients"],"prefix":"10.1017","volume":"151","author":[{"given":"Yangping","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qimeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoxing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1898-164X","authenticated-orcid":false,"given":"Haisheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"S0950268823000766_r4","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003423"},{"key":"S0950268823000766_r27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.annemergmed.2011.07.035","article-title":"Update on emerging infections: News from the Centers for Disease Control and Prevention. Vital signs: Central line-associated blood stream infections--United States, 2001, 2008, and 2009","volume":"58","author":"Liang","year":"2011","journal-title":"Annals of Emergency Medicine"},{"key":"S0950268823000766_r29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.12.008"},{"key":"S0950268823000766_r6","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12011116"},{"key":"S0950268823000766_r26","doi-asserted-by":"publisher","DOI":"10.1016\/j.aucc.2021.09.005"},{"key":"S0950268823000766_r12","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-014-0689-y"},{"key":"S0950268823000766_r3","doi-asserted-by":"publisher","DOI":"10.1038\/srep46066"},{"key":"S0950268823000766_r5","doi-asserted-by":"publisher","DOI":"10.3390\/nu14122532"},{"key":"S0950268823000766_r10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2022.154149"},{"key":"S0950268823000766_r14","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.997713"},{"key":"S0950268823000766_r7","first-page":"10578","article-title":"The effects of hemodynamic monitoring using the PiCCO system on critically ill patients","volume":"13","author":"Li","year":"2021","journal-title":"American Journal of Translational Research"},{"key":"S0950268823000766_r25","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e318254d4ab"},{"key":"S0950268823000766_r21","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2017.12.009"},{"key":"S0950268823000766_r28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2013.08.001"},{"key":"S0950268823000766_r13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.06.030"},{"key":"S0950268823000766_r16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"S0950268823000766_r9","doi-asserted-by":"publisher","DOI":"10.1111\/wvn.12548"},{"key":"S0950268823000766_r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2018.12.004"},{"key":"S0950268823000766_r20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.05.004"},{"key":"S0950268823000766_r19","first-page":"668","article-title":"Microbiological diagnosis of catheter-related infections.Enfermedades Infecciosas Y. Microbiologia","volume":"37","author":"Aldea","year":"2019","journal-title":"Clinica"},{"key":"S0950268823000766_r1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.03.006"},{"key":"S0950268823000766_r23","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000186"},{"key":"S0950268823000766_r24","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00351-2"},{"key":"S0950268823000766_r17","unstructured":"[17] NHSN. Patient Safety Component Manual, Chapter 4, Bloodstream Infection Event (Central Line-Associated Bloodstream Infection and Non-central Line Associated Bloodstream Infection) https:\/\/wwwcdcgov\/nhsn\/pdfs\/pscmanual\/pcsmanual_currentpdf2021 , 2021."},{"key":"S0950268823000766_r18","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06871-5"},{"key":"S0950268823000766_r22","first-page":"267","article-title":"Central venous catheter replacement in the ICU: New site versus guidewire exchange","volume":"73","author":"Castelli","year":"2007","journal-title":"Minerva Anestesiologica"},{"key":"S0950268823000766_r2","doi-asserted-by":"publisher","DOI":"10.1016\/j.afjem.2017.01.006"},{"key":"S0950268823000766_r11","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12665"},{"key":"S0950268823000766_r15","doi-asserted-by":"publisher","DOI":"10.21037\/jeccm.2018.05.05"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268823000766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T20:05:12Z","timestamp":1686081912000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268823000766\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":29,"alternative-id":["S0950268823000766"],"URL":"https:\/\/doi.org\/10.1017\/s0950268823000766","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e90"}}