{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:45:39Z","timestamp":1767833139492,"version":"3.49.0"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"unspecified","delay-in-days":159,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"funder":[{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1104403B"],"award-info":[{"award-number":["TCVGH-1104403B"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1114404B"],"award-info":[{"award-number":["TCVGH-1114404B"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Candidemia is a life-threatening infectious disease that has varying incidences. Previous studies revealed the differences in clinical characteristics and outcomes between non-hospital-onset (NHO) and hospital-onset (HO) candidemia. This 4-year retrospective research included adult patients with candidemia in a tertiary medical centre in Taiwan, and cases were categorised as NHO and HO candidemia. Survival analysis and risk factors associated with in-hospital mortality were performed using the Kaplan\u2013Meier method and multivariate Cox proportional-hazards models. The analysis included 339 patients, and the overall incidence was 1.50 per 1,000 admission person-year. Of the cases, 82 (24.18%) were NHO candidemia, and 57.52% (195\/339) of patients were diagnosed with at least one malignancy. <jats:italic>C. albicans<\/jats:italic> was the most commonly isolated species, accounting for 52.21%. Patients with NHO candidemia had a higher proportion of <jats:italic>C. glabrata<\/jats:italic> but a lower ratio of <jats:italic>C. tropicalis<\/jats:italic> in comparison to the HO group. The all-cause in-hospital mortality rate was 55.75%. Multivariate Cox proportional-hazards models showed that NHO candidemia was a better outcome predictor (adjusted hazard ratio, 0.44). The administration of antifungal therapy within 2\u00a0days was a protective factor. In conclusion, NHO candidemia showed distinct microbiological characteristics and a better outcome than HO candidemia.<\/jats:p>","DOI":"10.1017\/s0950268823000894","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T11:26:59Z","timestamp":1686310019000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Different epidemiological characteristics between patients with non-hospital-onset and hospital-onset candidemia: a retrospective cohort study"],"prefix":"10.1017","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9946-0685","authenticated-orcid":false,"given":"Yung-Chun","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao-Wang","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Cheng","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Chin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"S0950268823000894_r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.004"},{"key":"S0950268823000894_r15","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy358"},{"key":"S0950268823000894_r32","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12329"},{"key":"S0950268823000894_r3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2013.08.017"},{"key":"S0950268823000894_r6","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"S0950268823000894_r16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2019.01.002"},{"key":"S0950268823000894_r22","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-020-03863-2"},{"key":"S0950268823000894_r33","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis021"},{"key":"S0950268823000894_r29","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(09)60091-7"},{"key":"S0950268823000894_r9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165346"},{"key":"S0950268823000894_r23","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-05536-z"},{"key":"S0950268823000894_r11","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.26"},{"key":"S0950268823000894_r14","doi-asserted-by":"publisher","DOI":"10.1086\/504807"},{"key":"S0950268823000894_r26","first-page":"19","article-title":"Nosocomial candidemia in a university hospital in Taiwan","volume":"95","author":"Hung","year":"1996","journal-title":"Journal of the Formosan Medical Association"},{"key":"S0950268823000894_r13","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1061"},{"key":"S0950268823000894_r17","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab105"},{"key":"S0950268823000894_r1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy776"},{"key":"S0950268823000894_r7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.06.010"},{"key":"S0950268823000894_r25","doi-asserted-by":"publisher","DOI":"10.2307\/1934145"},{"key":"S0950268823000894_r24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2008.12.008"},{"key":"S0950268823000894_r20","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.9.3254-3259.2001"},{"key":"S0950268823000894_r21","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01079-10"},{"key":"S0950268823000894_r27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2010.12.007"},{"key":"S0950268823000894_r19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104702"},{"key":"S0950268823000894_r30","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2020.101008"},{"key":"S0950268823000894_r4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099103"},{"key":"S0950268823000894_r10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1315399"},{"key":"S0950268823000894_r35","first-page":"1","article-title":"Population-based active surveillance for culture-confirmed candidemia- four sites, United States, 2012-2016","volume":"68","author":"Toda","year":"2019","journal-title":"Morbidity and Mortality Weekly Report. 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e102"}}