{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:16:54Z","timestamp":1790223414137,"version":"4.1.0"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"unspecified","delay-in-days":159,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["PDF-2018-11-ST2-006"],"award-info":[{"award-number":["PDF-2018-11-ST2-006"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>In the UK, the incidence and prevalence of inflammatory bowel disease (IBD) is increasing in paediatric populations. Environmental factors including acute gastroenteritis episodes (AGE) may impact IBD development. Infant rotavirus vaccination has been shown to significantly reduce AGE. This study aims to explore the association between vaccination with live oral rotavirus vaccines and IBD development. A population-based cohort study was used, analysing primary care data from the Clinical Practice Research Datalink Aurum. Participants included children born in the UK from 2010 to 2015, followed from a minimum of 6\u00a0months old to a maximum of 7\u00a0years old. The primary outcome was IBD, and the primary exposure was rotavirus vaccination. Cox regression analysis with random intercepts for general practices was undertaken, with adjustment for potential confounding factors. In a cohort of 907,477 children, IBD was recorded for 96 participants with an incidence rate of 2.1 per 100,000 person-years at risk. The univariable analysis hazard ratio (HR) for rotavirus vaccination was 1.45 (95% confidence interval (CI) 0.93\u20132.28). Adjustment in the multivariable model attenuated the HR to 1.19 (95% CI 0.53\u20132.69). This study shows no statistically significant association between rotavirus vaccination and development of IBD. However, it provides further evidence for the safety of live rotavirus vaccination.<\/jats:p>","DOI":"10.1017\/s0950268823000936","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T11:26:57Z","timestamp":1686310017000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Investigating association between inflammatory bowel disease and rotavirus vaccination in a paediatric cohort in the UK"],"prefix":"10.1017","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0023-0976","authenticated-orcid":false,"given":"Aidan","family":"Flatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Inns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate M.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miren","family":"Iturriza-G\u00f3mara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-0163","authenticated-orcid":false,"given":"Daniel","family":"Hungerford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"S0950268823000936_r22","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.02.004"},{"key":"S0950268823000936_r32","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0473-3-17"},{"key":"S0950268823000936_r33","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac276"},{"key":"S0950268823000936_r17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvacx.2019.100005"},{"key":"S0950268823000936_r20","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13991"},{"key":"S0950268823000936_r11","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-015-0562-9"},{"key":"S0950268823000936_r24","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv098"},{"key":"S0950268823000936_r19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.09.034"},{"key":"S0950268823000936_r23","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.15830"},{"key":"S0950268823000936_r15","unstructured":"[15] Rivera-Dominguez, G and Ward, R (2018) Pediatric gastroenteritis [Online]. Available at https:\/\/europepmc.org\/article\/nbk\/nbk499939 (accessed 18 October 2022)."},{"key":"S0950268823000936_r13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.01.002"},{"key":"S0950268823000936_r4","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01716-6"},{"key":"S0950268823000936_r28","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0989-z"},{"key":"S0950268823000936_r2","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldab010"},{"key":"S0950268823000936_r14","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.83"},{"key":"S0950268823000936_r5","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-313955"},{"key":"S0950268823000936_r10","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2018.16.1.26"},{"key":"S0950268823000936_r9","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30267-3"},{"key":"S0950268823000936_r16","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.09.059"},{"key":"S0950268823000936_r12","doi-asserted-by":"publisher","DOI":"10.5009\/gnl15491"},{"key":"S0950268823000936_r1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60750-8"},{"key":"S0950268823000936_r18","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.054353"},{"key":"S0950268823000936_r6","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.1982"},{"key":"S0950268823000936_r30","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12766"},{"key":"S0950268823000936_r25","unstructured":"[25] Public Health England (2014) Rotavirus infant immunisation programme 2014 to 2015."},{"key":"S0950268823000936_r29","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-021-02017-1"},{"key":"S0950268823000936_r3","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2014-100514"},{"key":"S0950268823000936_r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.05.032"},{"key":"S0950268823000936_r26","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.09.051"},{"key":"S0950268823000936_r31","unstructured":"[31] GOV.UK (2022) Vaccine Uptake Guidance and the Latest Coverage Data \u2013 GOV.UK. Available at https:\/\/www.gov.uk\/government\/collections\/vaccine-uptake#cover-of-vaccination-evaluated- (accessed 6 November 2022)."},{"key":"S0950268823000936_r7","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2010.510575"},{"key":"S0950268823000936_r21","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.081"},{"key":"S0950268823000936_r27","doi-asserted-by":"publisher","DOI":"10.1016\/S2589-7500(19)30012-3"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268823000936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T08:42:44Z","timestamp":1687768964000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268823000936\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":33,"alternative-id":["S0950268823000936"],"URL":"https:\/\/doi.org\/10.1017\/s0950268823000936","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e103"}}