{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:51:48Z","timestamp":1774579908341,"version":"3.50.1"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"unspecified","delay-in-days":200,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Varicella vaccination is optional and requires self-payment. On 1 December 2018, Wuxi City launched a free varicella vaccination program for children. This study aimed to evaluate the changes in varicella incidence before and after the implementation of the policy. The data were obtained from official information systems and statistical yearbooks. We divided the period into chargeable (January 2017 to November 2018) and free (December 2018 to December 2021) periods. Interrupt time series analysis was used to conduct a generalised least-squares regression analysis for the two periods. A total of 51,071 varicella cases were reported between January 2017 and December 2021. After the implementation of the policy, there was a statistically significant decrease in the incidence of varicella (\u03b22 = \u22120.140, P = 0.017), and the slope of the incidence also decreased by 0.012 (P = 0.015). Following policy implementation, the incidence decreased in all age groups, with the largest decline observed among children aged 8\u201314 years (\u03b22 = \u22121.109, P = 0.009), followed by children aged \u22647 years (\u03b22 = \u22120.894, P = 0.013). Our study found a significant reduction in the incidence of varicella in the total population after the introduction of free varicella vaccination in Wuxi City.<\/jats:p>","DOI":"10.1017\/s0950268823001152","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T07:32:11Z","timestamp":1689838331000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Impact of implementing a free varicella vaccination policy on incidence in Wuxi City, China: an interrupted time series analysis"],"prefix":"10.1017","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4919-8790","authenticated-orcid":false,"given":"Shixin","family":"Xiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0071-9755","authenticated-orcid":false,"given":"Hui","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"S0950268823001152_r1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69561-5"},{"key":"S0950268823001152_r26","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.138777"},{"key":"S0950268823001152_r12","first-page":"78","article-title":"Varicella","volume":"15","author":"Xu","year":"2009","journal-title":"Zhongguo Yi Miao He Mian Yi"},{"key":"S0950268823001152_r11","first-page":"3","article-title":"Meta-analysis of varicella vaccine coverage among Chinese children","volume":"6","author":"Liu","year":"2017","journal-title":"Chinese Journal of Vaccines and Immunization"},{"key":"S0950268823001152_r4","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.7.6.753"},{"key":"S0950268823001152_r5","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9121485"},{"key":"S0950268823001152_r19","doi-asserted-by":"publisher","DOI":"10.1002\/sim.9669"},{"key":"S0950268823001152_r3","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.01.061"},{"key":"S0950268823001152_r15","unstructured":"[15] Wuxi City Bureau of Statistics (2019) Wuxi Statistical Yearbook. Available at http:\/\/tj.wuxi.gov.cn\/doc\/2019\/09\/12\/2655098.shtml (accessed 26 February 2023)."},{"key":"S0950268823001152_r23","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2022.2143176"},{"key":"S0950268823001152_r18","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-021-01364-0"},{"key":"S0950268823001152_r28","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1958608"},{"key":"S0950268823001152_r32","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac337"},{"key":"S0950268823001152_r8","unstructured":"[8] World Health Organization (2023) Introduction of Varicella vaccine. Available at https:\/\/immunizationdata.who.int\/pages\/vaccine-intro-by-antigen\/varicella.html?ISO_3_CODE=&YEAR= (accessed 18 January 2023)."},{"key":"S0950268823001152_r6","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1708"},{"key":"S0950268823001152_r17","first-page":"348","article-title":"Interrupted time series regression for the evaluation of public health interventions: A tutorial","volume":"46","author":"Bernal","year":"2017","journal-title":"International Journal of Epidemiology"},{"key":"S0950268823001152_r35","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07301-w"},{"key":"S0950268823001152_r10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0270630"},{"key":"S0950268823001152_r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2022.100639"},{"key":"S0950268823001152_r2","unstructured":"[2] World Health Organization (2014) Varicella and herpes zoster vaccines: WHO position paper, June 2014. Available at https:\/\/www.who.int\/publications\/i\/item\/who-wer-8925-265-288 (accessed 18 January 2023)."},{"key":"S0950268823001152_r14","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2022.2094641"},{"key":"S0950268823001152_r13","first-page":"374","article-title":"Economic evaluation of different chickenpox vaccination strategies","volume":"47","author":"Deng","year":"2018","journal-title":"Zhejiang Da Xue Xue Bao. Yi Xue Ban"},{"key":"S0950268823001152_r22","first-page":"1","article-title":"Advisory committee on immunization practices, Centers for Disease Control and Prevention (CDC) (2007) prevention of varicella: Recommendations of the advisory committee on immunization practices (ACIP)","volume":"56","author":"Marin","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"S0950268823001152_r24","first-page":"587","article-title":"Comparison of epidemic characteristics and clinical manifestation of chickenpox between adults and children in Shandong Province from 2019 to 2021","volume":"44","author":"Luan","year":"2023","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"S0950268823001152_r25","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-12898-3"},{"key":"S0950268823001152_r21","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.08.022"},{"key":"S0950268823001152_r30","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2019.1663121"},{"key":"S0950268823001152_r16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.10.016"},{"key":"S0950268823001152_r34","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.352"},{"key":"S0950268823001152_r33","first-page":"2001600","article-title":"Decline of influenza and respiratory syncytial virus detection in facility-based surveillance during the COVID-19 pandemic, South Africa, January to October 2020","volume":"26","author":"Tempia","year":"2021","journal-title":"Euro Surveillance"},{"key":"S0950268823001152_r20","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy954"},{"key":"S0950268823001152_r7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251644"},{"key":"S0950268823001152_r29","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.05.025"},{"key":"S0950268823001152_r27","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2020.1769395"},{"key":"S0950268823001152_r31","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000444"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268823001152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T10:19:20Z","timestamp":1691144360000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268823001152\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":35,"alternative-id":["S0950268823001152"],"URL":"https:\/\/doi.org\/10.1017\/s0950268823001152","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e125"}}