{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:17:06Z","timestamp":1790295426941,"version":"4.1.0"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"unspecified","delay-in-days":267,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Maternal syphilis not only seriously affects the quality of life of pregnant women themselves but also may cause various adverse pregnancy outcomes (APOs). This study aimed to analyse the association between the related factors and APOs in maternal syphilis. 7,030 pregnant women infected with syphilis in Henan Province between January 2016 and December 2022 were selected as participants. Information on their demographic and clinical characteristics, treatment status, and pregnancy outcomes was collected. Multivariate logistic regression models and chi-squared automatic interaction detector (CHAID) decision tree models were used to analyse the factors associated with APOs. The multivariate logistic regression results showed that the syphilis infection history (OR\u00a0=\u00a01.207, 95% CI, 1.035\u20131.409), the occurrence of abnormality during pregnancy (OR\u00a0=\u00a05.001, 95% CI, 4.203\u20135.951), not receiving standard treatment (OR\u00a0=\u00a01.370, 95% CI, 1.095\u20131.716), not receiving any treatment (OR\u00a0=\u00a01.313, 95% CI, 1.105\u20131.559), and a titre \u22651:8 at diagnosis (OR\u00a0=\u00a01.350, 95%CI, 1.079\u20131.690) and before delivery (OR\u00a0=\u00a01.985, 95%CI, 1.463\u20132.694) were risk factors. A total of six influencing factors of APOs in syphilis-infected women were screened using the CHAID decision tree model. Integrated prevention measures such as early screening, scientific eugenics assessment, and standard syphilis treatment are of great significance in reducing the incidence of APOs for pregnant women infected with syphilis.<\/jats:p>","DOI":"10.1017\/s0950268823001589","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T08:12:15Z","timestamp":1695629535000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Factors associated with adverse pregnancy outcomes of maternal syphilis in Henan, China, 2016\u20132022"],"prefix":"10.1017","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2971-5109","authenticated-orcid":false,"given":"Meng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfen","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cannan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengcai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"S0950268823001589_r20","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-3896-4"},{"key":"S0950268823001589_r27","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2017-0027"},{"key":"S0950268823001589_r2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-022-05258-x"},{"key":"S0950268823001589_r5","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2021.1895740"},{"key":"S0950268823001589_r24","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-021-02502-9"},{"key":"S0950268823001589_r26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.02.037"},{"key":"S0950268823001589_r17","first-page":"433","article-title":"Maternal syphilis: Pathophysiology and treatment","volume":"82","author":"Berman","year":"2004","journal-title":"Bulletin of the World Health Organization"},{"key":"S0950268823001589_r30","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.183863"},{"key":"S0950268823001589_r12","unstructured":"[12] National Health and Family Planning Commission of the People\u2019s Republic of China. [Internet]. National Program for Prevention and Control of Syphilis Program (2010\u20132020). [Cited 2023 March 23]. Available at http:\/\/www.nhc.gov.cn\/wjw\/gfxwj\/201304\/bb67c7a0e7c140d7b5ad25ca5106b659.shtml (accessed May 2023)."},{"key":"S0950268823001589_r33","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-018132"},{"key":"S0950268823001589_r18","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2020.11.009"},{"key":"S0950268823001589_r7","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16554"},{"key":"S0950268823001589_r34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.04.015"},{"key":"S0950268823001589_r3","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.12.107623"},{"key":"S0950268823001589_r11","unstructured":"[11] World Health Organization. [Internet]. Welcome to 2020-the decade for disease elimination. [Cited 2023 March 23]. Available at https:\/\/www.who.int\/news-room\/feature-stories\/detail\/welcome-to-2020-the-decade-for-disease-elimination (accessed May 2023)."},{"key":"S0950268823001589_r8","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(21)00171-3"},{"key":"S0950268823001589_r1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac427"},{"key":"S0950268823001589_r10","unstructured":"[10] World Health Organization. [Internet]. The Global elimination of congenital syphilis: rationale and strategy for action, [Cited 2023 March 23]. Available at https:\/\/www.who.int\/publications\/i\/item\/9789241595858 (accessed May 2023)."},{"key":"S0950268823001589_r4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2023.100957"},{"key":"S0950268823001589_r6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211720"},{"key":"S0950268823001589_r9","unstructured":"[9] China National Bureau of Statistics. [Internet]. Category A and B statutory reporting of infectious disease incidence [Cited 2023 March 23]. Available at https:\/\/data.stats.gov.cn\/easyquery.htm?cn=C01 (accessed July 2023)."},{"key":"S0950268823001589_r32","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000875"},{"key":"S0950268823001589_r13","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.14.139626"},{"key":"S0950268823001589_r14","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000713"},{"key":"S0950268823001589_r16","doi-asserted-by":"publisher","DOI":"10.1016\/j.wombi.2018.11.004"},{"key":"S0950268823001589_r29","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-05946-7"},{"key":"S0950268823001589_r28","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac128"},{"key":"S0950268823001589_r31","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.13424"},{"key":"S0950268823001589_r23","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.33413"},{"key":"S0950268823001589_r25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.11.1052"},{"key":"S0950268823001589_r22","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2721-1"},{"key":"S0950268823001589_r19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010884"},{"key":"S0950268823001589_r15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102203"},{"key":"S0950268823001589_r21","first-page":"1284","article-title":"Analysis of adverse pregnancy outcomes and related factors in pregnant women with syphilis infection in Guangxi of China, 2014-2018","volume":"53","author":"Qin","year":"2019","journal-title":"Chinese Journal of Preventive medicine"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268823001589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T10:12:50Z","timestamp":1697191970000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268823001589\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":34,"alternative-id":["S0950268823001589"],"URL":"https:\/\/doi.org\/10.1017\/s0950268823001589","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e170"}}