{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:16:13Z","timestamp":1782836173724,"version":"3.54.5"},"reference-count":43,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"unspecified","delay-in-days":276,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Knowing the burden of severe disease caused by influenza is essential for disease risk communication, to understand the true impact of vaccination programmes and to guide public health and disease control measures. We estimated the number of influenza-attributable hospitalisations in Spain during the 2010\u20132011 to 2019\u20132020 seasons \u2013 based on the hospitalisations due to severe acute respiratory infection (SARI) in Spain using the hospital discharge database and virological influenza information from the Spanish Influenza Sentinel Surveillance System (SISSS). The weekly numbers of influenza-attributable hospitalisations were calculated by multiplying the weekly SARI hospitalisations by the weekly influenza virus positivity, obtained from the SISSS in each season, stratified by age group and sex. The influenza-related hospitalisation burden is age-specific and varies significantly by influenza season. People aged 65 and over yielded the highest average influenza-attributable hospitalisation rates per season (615.6 per 100,000), followed by children aged under 5 (251.2 per 100,000). These results provide an essential contribution to influenza control and to improving existing vaccination programmes, as well as to the optimisation and planning of health resources and policies.<\/jats:p>","DOI":"10.1017\/s0950268823001620","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T09:15:47Z","timestamp":1696410947000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Influenza hospitalisations in Spain between the last influenza and COVID-19 pandemic (2009\u20132019)"],"prefix":"10.1017","volume":"151","author":[{"given":"Javier","family":"Canelas-Fern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Mazagatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Delgado-Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1704-2245","authenticated-orcid":false,"given":"Amparo","family":"Larrauri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"S0950268823001620_r22","unstructured":"[22] Instituto de Salud Carlos III. Carga de enfermedad de la gripe estacional e impacto de la vacuna antigripal. Infograf\u00edas, temporadas 2017\u20132018 a 2019\u20132020. Available at https:\/\/www.isciii.es\/QueHacemos\/Servicios\/VigilanciaSaludPublicaRENAVE\/EnfermedadesTransmisibles\/Paginas\/Infograf%C3%ADas.aspx."},{"key":"S0950268823001620_r5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30129-0"},{"key":"S0950268823001620_r18","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12022"},{"key":"S0950268823001620_r9","unstructured":"[9] European Centre for Disease Prevention and Control . Seasonal Influenza Vaccination in Europe: Vaccination Recommendations and Coverage Rates in the EU Member States for Eight Influenza Seasons 2007\u20132008 to 2014\u20132015. LU. Publications Office: 2017."},{"key":"S0950268823001620_r23","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12499"},{"key":"S0950268823001620_r27","unstructured":"[27] Ministerio de Sanidad. Registro de Actividad Sanitaria Especializada (RAE-CMBD): Actividad y resultados de la hospitalizaci\u00f3n en el SNS. A\u00f1o 2018."},{"key":"S0950268823001620_r20","doi-asserted-by":"crossref","unstructured":"[20] Goldstein, E (2019) Influenza-associated mortality for different causes of death during the 2010\u20132011 through the 2014\u20132015 influenza seasons in Russia. Epidemiology.","DOI":"10.1101\/19005470"},{"key":"S0950268823001620_r28","unstructured":"[28] I-MOVE+ (2019) Protocol for hospital-based test negative case control studies to measure seasonal influenza vaccine effectiveness against influenza laboratory confirmed SARI hospitalisation among the elderly across the European Union and European Economic Area Member States."},{"key":"S0950268823001620_r30","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2017.1343226"},{"key":"S0950268823001620_r34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.11.013"},{"key":"S0950268823001620_r36","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-016-3378-1"},{"key":"S0950268823001620_r7","unstructured":"[7] World Health Organization. Recommended composition of influenza virus vaccines for use in the 2023 southern hemisphere influenza season. Available at https:\/\/www.who.int\/publications\/m\/item\/recommended-composition-of-influenza-virus-vaccines-for-use-in-the-2023-southern-hemisphere-influenza-season (accessed 9 May 2023)."},{"key":"S0950268823001620_r14","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1186\/s12889-019-7958-8","article-title":"Impact of national influenza vaccination strategy in severe influenza outcomes among the high-risk Portuguese population","volume":"19","author":"Machado","year":"2019","journal-title":"BMC Public Health"},{"key":"S0950268823001620_r12","unstructured":"[12] Ministerio de Sanidad. Evoluci\u00f3n de cobertura de vacunaci\u00f3n frente a la gripe en poblaci\u00f3n \u2265 65 a\u00f1os. Espa\u00f1a, temporadas de 2011\u20132012 a 2019\u20132020."},{"key":"S0950268823001620_r13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221479"},{"key":"S0950268823001620_r6","unstructured":"[6] World Health Organization. Recommended composition of influenza virus vaccines for use in the 2023\u20132024 northern hemisphere influenza season. Available at https:\/\/www.who.int\/publications\/m\/item\/recommended-composition-of-influenza-virus-vaccines-for-use-in-the-2023-2024-northern-hemisphere-influenza-season (accessed 9 May 2023)."},{"key":"S0950268823001620_r25","unstructured":"[25] Instituto de Salud Carlos III. Sistema de Vigilancia de Gripe en Espa\u00f1a. Informes anuales, temporadas 1999\/2000\u20132019\u20132020 (Influenza Surveillance in Spain. Annual reports, seasons 1999\/2000\u20132019\u20132020). Available at https:\/\/www.isciii.es\/QueHacemos\/Servicios\/VigilanciaSaludPublicaRENAVE\/EnfermedadesTransmisibles\/Paginas\/Informes-anuales.aspx."},{"key":"S0950268823001620_r39","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12319"},{"key":"S0950268823001620_r41","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4621-z"},{"key":"S0950268823001620_r26","doi-asserted-by":"publisher","DOI":"10.1016\/S0213-005X(12)70098-8"},{"key":"S0950268823001620_r4","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.11.080"},{"key":"S0950268823001620_r33","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4308-5"},{"key":"S0950268823001620_r16","unstructured":"[16] Centers for Disease Control and Prevention (CDC). Disease Burden of Flu in the U.S. from 2010\u20132020. Available at https:\/\/www.cdc.gov\/flu\/about\/burden\/index.html."},{"key":"S0950268823001620_r21","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12501"},{"key":"S0950268823001620_r35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.02.011"},{"key":"S0950268823001620_r40","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12434"},{"key":"S0950268823001620_r3","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2017.1367463"},{"key":"S0950268823001620_r43","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-3681-4"},{"key":"S0950268823001620_r1","unstructured":"[1] World Health Organization. Influenza (seasonal) factsheet. Available at http:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/influenza-(seasonal)."},{"key":"S0950268823001620_r32","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2018.11.014"},{"key":"S0950268823001620_r11","unstructured":"[11] Ministerio de Sanidad and Gobierno de Espa\u00f1a (2022) Recomendaciones de vacunaci\u00f3n frente a la gripe. Temporada 2022\u20132023."},{"key":"S0950268823001620_r38","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268814003422"},{"key":"S0950268823001620_r10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1590\/S1135-57272004000400006","article-title":"Evoluci\u00f3n de las coberturas vacunales antigripales entre 1993\u20132001 en Espa\u00f1a: An\u00e1lisis por Comunidades Aut\u00f3nomas","volume":"78","author":"Mayo Montero","year":"2004","journal-title":"Revista Espa\u00f1ola de Salud P\u00fablica"},{"key":"S0950268823001620_r15","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12486"},{"key":"S0950268823001620_r17","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1093\/cid\/cis211","article-title":"Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993\u20132008","volume":"54","author":"Zhou","year":"2012","journal-title":"Clinical Infectious Diseases"},{"key":"S0950268823001620_r24","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-7-197"},{"key":"S0950268823001620_r8","unstructured":"[8] European Centre for Disease Prevention and Control (2018) Seasonal influenza vaccination and antiviral use in EU\/EEA Member States\u2013Overview of vaccine recommendations for 2017\u20132018 and vaccination coverage rates for 2015\u20132016 and 2016\u20132017 influenza seasons. Published online: 2018."},{"key":"S0950268823001620_r37","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3181-y"},{"key":"S0950268823001620_r29","unstructured":"[29] European Centre for Disease Prevention and Control. Core protocol for ECDC studies of COVID-19 vaccine effectiveness against hospitalisation with Severe Acute Respiratory Infection, laboratory-confirmed with SARS-CoV-2 or with seasonal influenza - Version 2.0. Available at https:\/\/www.ecdc.europa.eu\/en\/publications-data\/core-protocol-ecdc-studies-covid-19-vaccine-effectiveness-against-0 (accessed 28 May 2023)."},{"key":"S0950268823001620_r2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33293-2"},{"key":"S0950268823001620_r42","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2539-x"},{"key":"S0950268823001620_r19","first-page":"8","article-title":"Influenza-associated hospitalisations in Finland from 1996 to 2010: Unexpected age-specific burden during the influenza A(H1N1)pdm09 pandemic from 2009 to 2010","volume":"17","author":"Jacks","year":"2012","journal-title":"Euro Surveillance"},{"key":"S0950268823001620_r31","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/irv.12502","article-title":"Estimating the burden of influenza-associated hospitalizations and deaths in Chile during 2012\u20132014","volume":"12","author":"Sotomayor","year":"2018","journal-title":"Influenza and Other Respiratory Viruses"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268823001620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T05:42:22Z","timestamp":1697694142000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268823001620\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":43,"alternative-id":["S0950268823001620"],"URL":"https:\/\/doi.org\/10.1017\/s0950268823001620","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e177"}}