{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:57:38Z","timestamp":1747173458593,"version":"3.40.5"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p><jats:italic>Plasmodium vivax<\/jats:italic> is the most frequent and widely distributed cause of recurring malaria. It is a public health issue that mostly occurs in Southeast Asia, followed by the Middle East, Latin, and South Americas and sub-Saharan Africa. Although it is commonly known as an etiologic agent of malaria with mild clinical manifestations, it can lead to severe complications. It has been neglected and understudied for a long time, due to its low mortality, culturing infeasibility, and mild clinical manifestations in comparison to <jats:italic>P. falciparum.<\/jats:italic> Despite the mild clinical issues commonly rose for <jats:italic>P. vivax<\/jats:italic>, the correlation between the clinical manifestations exhibited by patients with severe and non-severe complications and the genetic diversity of parasites responsible for the disease is not clear. An investigation was carried out between 2011 and 2021 on patients referred to Avicenne Hospital for suspected <jats:italic>P. vivax<\/jats:italic> infection. Upon arrival, they underwent clinical and biological examinations. The lateral flow test and LAMP-PCR confirmed the presence of malaria parasites, <jats:italic>Plasmodium<\/jats:italic> sp\u2025 Microscopic examination revealed the presence of <jats:italic>Plasmodium<\/jats:italic> parasites with a parasitaemia between 0.01 and 0.38%. Conventional PCR amplifications targeting 714\u00a0bp DNA fragment of small subunit ribosomal DNA (SSU-rDNA) followed by bidirectional sequencing allowed us to identify the parasites as <jats:italic>P. vivax.<\/jats:italic> The neighbor-joining (NJ) phylogenetic tree revealed that <jats:italic>P. vivax<\/jats:italic> sequences processed in the present study clustered in two well-differentiated and supported clades. It included a bigger clade including <jats:italic>P. vivax<\/jats:italic> specimens of all our patients together with homonymous sequences from Indonesia, India, and El Salvador and the second clade encompassed the sequences from Yemen and India. In addition, the clustering displayed by the median-joining network agreed well with the topology of the phylogenetic tree generated by the neighbor-joining analysis. No correlation between the clinical manifestation of patients with severe and non-severe complications, encompassing diverse geographical origins, and the genetic diversity of parasites was observed since all sequences demonstrated a high homogeneity. These findings can be helpful in getting knowledge about the population genetics of <jats:italic>P. vivax<\/jats:italic> and taking proper control management strategies against these parasites.<\/jats:p>","DOI":"10.1017\/s0950268823001632","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:59:05Z","timestamp":1696237145000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Genetic diversity of <i>Plasmodium vivax<\/i> in immigrant patients exhibiting severe and non-severe clinical manifestations in northern suburbs of Paris"],"prefix":"10.1017","volume":"152","author":[{"given":"Adama","family":"Soumaoro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Hamarsheh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Marteau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Brun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Bouchaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Adnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Thellier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Houze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arezki","family":"Izri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4672-9836","authenticated-orcid":false,"given":"Mohammad","family":"Akhoundi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,10,2]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268823001632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T02:58:09Z","timestamp":1729220289000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268823001632\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,2]]},"references-count":0,"alternative-id":["S0950268823001632"],"URL":"https:\/\/doi.org\/10.1017\/s0950268823001632","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"type":"print","value":"0950-2688"},{"type":"electronic","value":"1469-4409"}],"subject":[],"published":{"date-parts":[[2023,10,2]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e127"}}