{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:51:38Z","timestamp":1774619498906,"version":"3.50.1"},"reference-count":53,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"unspecified","delay-in-days":289,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Aspergillosis is a rising concern worldwide; however, its prevalence is not well documented in China. This retrospective study determined <jats:italic>Aspergillus\u2019s<\/jats:italic> epidemiology and antifungal susceptibilities at Meizhou People\u2019s Hospital, South China. From 2017 to 2022, the demographic, clinical, and laboratory data about aspergillosis were collected from the hospital\u2019s records and analysed using descriptive statistics, chi-square test, and ANOVA. Of 474 aspergillosis cases, <jats:italic>A. fumigatus<\/jats:italic> (75.32%) was the most common, followed by <jats:italic>A. niger<\/jats:italic> (9.92%), <jats:italic>A. flavus<\/jats:italic> (8.86%), and <jats:italic>A. terreus<\/jats:italic> (5.91%). A 5.94-fold increase in aspergillosis occurred during the study duration, with the highest cases reported from the intensive care unit (52.74%) \u2013 chronic pulmonary aspergillosis (79.1%) and isolated from sputum (62.93%). Only 38 (8.02%) patients used immunosuppressant drugs, while gastroenteritis (5.7%), haematologic malignancy (4.22%), and cardiovascular disease (4.22%) were the most prevalent underlying illnesses. In <jats:italic>A. fumigatus,<\/jats:italic> the wild-type (WT) isolates against amphotericin B (99.1%) were higher than triazoles (97\u201398%), whereas, in non-<jats:italic>fumigatus Aspergillus<\/jats:italic> species, the triazole (95\u2013100%) WT proportion was greater than amphotericin B (91\u201395%). Additionally, there were significantly fewer WT <jats:italic>A. fumigatus<\/jats:italic> isolates for itraconazole and posaconazole in outpatients than inpatients. These findings may aid in better understanding and management of aspergillosis in the region.<\/jats:p>","DOI":"10.1017\/s095026882300167x","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T08:47:13Z","timestamp":1697532433000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Epidemiology and antifungal susceptibilities of clinically isolated <i>Aspergillus<\/i> species in South China"],"prefix":"10.1017","volume":"151","author":[{"given":"Hazrat","family":"Bilal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongxing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Shafiq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Nadeem","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canhua","family":"chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabir","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahat Ullah","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-7562","authenticated-orcid":false,"given":"Yuebin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"S095026882300167X_r17","unstructured":"[17] Wayne, P (2017) Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi. Clinical and Laboratory Standards Institute (CLSI) document M37-A3."},{"key":"S095026882300167X_r7","doi-asserted-by":"publisher","DOI":"10.3390\/jof5020041"},{"key":"S095026882300167X_r36","first-page":"603","article-title":"Clinical spectrum of pulmonary aspergillosis","volume":"14","author":"Dogar","year":"2023","journal-title":"Journal of Pharmaceutical Negative Results"},{"key":"S095026882300167X_r43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0259766"},{"key":"S095026882300167X_r45","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-021-00923-4"},{"key":"S095026882300167X_r26","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2015.35.6.602"},{"key":"S095026882300167X_r48","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30316-X"},{"key":"S095026882300167X_r44","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10101303"},{"key":"S095026882300167X_r4","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"S095026882300167X_r8","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piad014"},{"key":"S095026882300167X_r22","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30443-7"},{"key":"S095026882300167X_r31","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myab064"},{"key":"S095026882300167X_r35","doi-asserted-by":"publisher","DOI":"10.24018\/ejbio.2022.3.2.361"},{"key":"S095026882300167X_r49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.09.002"},{"key":"S095026882300167X_r39","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-011-9427-5"},{"key":"S095026882300167X_r41","doi-asserted-by":"publisher","DOI":"10.1016\/j.buildenv.2021.108258"},{"key":"S095026882300167X_r1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.680884"},{"key":"S095026882300167X_r51","doi-asserted-by":"publisher","DOI":"10.3201\/eid2601.190885"},{"key":"S095026882300167X_r6","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ885"},{"key":"S095026882300167X_r16","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimce.2020.02.016"},{"key":"S095026882300167X_r20","volume-title":"Epidemiological Cutoff Values for Antifungal Susceptibility Testing","author":"Procop","year":"2020"},{"key":"S095026882300167X_r21","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2022.101330"},{"key":"S095026882300167X_r28","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01582-14"},{"key":"S095026882300167X_r25","doi-asserted-by":"publisher","DOI":"10.3390\/jof8030264"},{"key":"S095026882300167X_r34","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-020-01259-8"},{"key":"S095026882300167X_r46","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0244-2"},{"key":"S095026882300167X_r13","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1751"},{"key":"S095026882300167X_r52","first-page":"125","article-title":"Global pesticide consumption and pollution: With China as a focus","volume":"1","author":"Zhang","year":"2011","journal-title":"Proceedings of the International Academy of Ecology and Environmental Sciences"},{"key":"S095026882300167X_r11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2019.08.007"},{"key":"S095026882300167X_r37","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2486-0"},{"key":"S095026882300167X_r53","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00720-1"},{"key":"S095026882300167X_r23","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008315"},{"key":"S095026882300167X_r14","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00583-2015"},{"key":"S095026882300167X_r10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009711"},{"key":"S095026882300167X_r47","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2022.2123325"},{"key":"S095026882300167X_r32","volume-title":"Open Forum Infectious Diseases","author":"Ward","year":"2021"},{"key":"S095026882300167X_r29","doi-asserted-by":"publisher","DOI":"10.3390\/jof7050367"},{"key":"S095026882300167X_r12","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00708-23"},{"key":"S095026882300167X_r19","first-page":"1","article-title":"Reference method for broth dilution antifungal susceptibility testing of filamentous fungi, approved standard. M38-A2","volume":"28","author":"John","year":"2008","journal-title":"Clinical and Laboratory Standards Institute (CLSI)"},{"key":"S095026882300167X_r2","volume-title":"StatPearls (Internet)","author":"Vuong","year":"2022"},{"key":"S095026882300167X_r24","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2017.1283986"},{"key":"S095026882300167X_r30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073747"},{"key":"S095026882300167X_r33","first-page":"64","article-title":"A cross sectional study for clinico mycological profile of Otomycosis in North Karnataka","volume":"4","author":"Nandyal","year":"2015","journal-title":"International Journal of Medical and Health Sciences"},{"key":"S095026882300167X_r40","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2020.101011"},{"key":"S095026882300167X_r5","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-022-01960-2"},{"key":"S095026882300167X_r38","doi-asserted-by":"publisher","DOI":"10.25258\/ijpcr.v9i08.9583"},{"key":"S095026882300167X_r42","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00140-18"},{"key":"S095026882300167X_r50","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.10.3085-3088.2003"},{"key":"S095026882300167X_r3","doi-asserted-by":"publisher","DOI":"10.3201\/eid2609.200016"},{"key":"S095026882300167X_r15","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2021.03.008"},{"key":"S095026882300167X_r27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.10.021"},{"key":"S095026882300167X_r9","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.00280-22"},{"key":"S095026882300167X_r18","volume-title":"Performance Standards for Antifungal Susceptibility Testing of Yeasts","author":"Alexander","year":"2017"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S095026882300167X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T05:43:20Z","timestamp":1699595000000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S095026882300167X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":53,"alternative-id":["S095026882300167X"],"URL":"https:\/\/doi.org\/10.1017\/s095026882300167x","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e184"}}