{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:53:20Z","timestamp":1790834000063,"version":"4.1.0"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"unspecified","delay-in-days":102,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>The global incidence of syphilis is increasing. Continuity of care challenges the control of sexually transmitted diseases. In this study, we assessed the follow-up and serological decline differences between community- and hospital-diagnosed patients in Israel. A historical cohort study was conducted using the Israel National Syphilis Center (NSC) repository. Patients with a positive non-specific Venereal Disease Research Laboratory (VDRL) test between 2011 and 2020 were included. Rates of serological follow-up and serological titre decreases were compared between hospital- and community-diagnosed patients. The study included 4,445 patients, 2,596 (58.4%) were diagnosed in community clinics and 1,849 (41.6%) in hospitals. Of community-diagnosed patients, 1,957 (75.4%) performed follow-up testing, compared with 834 (51.2%) hospital-diagnosed patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). On multivariate analysis, the odds ratio of serology follow-up among community-diagnosed patients was 2.8 (95 per cent confidence interval (95% CI): 2.2\u20133.5) that of hospital-diagnosed patients. There were 1,397 (71.4%) community-diagnosed patients with serological titre decrease, compared with 626 (74.9%) hospital-diagnosed patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03). On multivariate analysis, this difference diminished. Serological follow-up testing is suboptimal and was performed more often among patients initially diagnosed in the community compared to hospitals. Continuity of care should be improved to promote successful patient care and prevent disease spread.<\/jats:p>","DOI":"10.1017\/s0950268824000566","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T09:57:50Z","timestamp":1712915870000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Serological follow-up after syphilis diagnosis in Israel"],"prefix":"10.1017","volume":"152","author":[{"given":"Galia","family":"Grauenfels Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0091-2216","authenticated-orcid":false,"given":"Matan J.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze\u2019ev","family":"Dveyrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohar","family":"Mor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrat","family":"Rorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehud","family":"Kaliner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"S0950268824000566_r3","doi-asserted-by":"publisher","DOI":"10.1071\/SH22134"},{"key":"S0950268824000566_r11","first-page":"1","article-title":"CDC laboratory recommendations for syphilis testing, United States, 2024","volume":"73","author":"Papp","year":"2024","journal-title":"Morbidity and Mortality Weekly Report. Recommendations and Reports"},{"key":"S0950268824000566_r16","unstructured":"[16] WHO (2017) Guideline on Syphilis Screening and Treatment for Pregnant Women. WHO Guidelines Approved by the Guidelines Review Committee. Geneva."},{"key":"S0950268824000566_r1","unstructured":"[1] WHO (2016) WHO Guidelines for the Treatment of Treponema pallidum (Syphilis). Geneva. Available at http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=27631046."},{"key":"S0950268824000566_r6","volume-title":"Notifiable Infectious Diseases in Israel: 65 Years of Surveillance 1951 to 2015","year":"2020"},{"key":"S0950268824000566_r7","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00686-22"},{"key":"S0950268824000566_r9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204001"},{"key":"S0950268824000566_r19","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis918"},{"key":"S0950268824000566_r17","unstructured":"[17] WHO (2022) Global health sector strategies on, respectively, HIV, viral hepatitis and sexually transmitted infections for the period 2022\u20132030, Licence: CC BY-NC-SA 3.0 IGO."},{"key":"S0950268824000566_r13","unstructured":"[13] WHO (2007) The global elimination of congenital syphilis: Rationale and strategy for action. Available at https:\/\/www.who.int\/publications\/i\/item\/9789241595858."},{"key":"S0950268824000566_r5","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2003.08.002"},{"key":"S0950268824000566_r4","first-page":"1","article-title":"Sexually transmitted infections treatment guidelines, 2021","volume":"70","author":"Workowski","year":"2021","journal-title":"Morbidity and Mortality Weekly Report. Recommendations and Reports"},{"key":"S0950268824000566_r18","first-page":"255","article-title":"Is repeated retreatment necessary for HIV-negative serofast early syphilis patients?","volume":"19","author":"Liu","year":"2020","journal-title":"Experimental and Therapeutic Medicine"},{"key":"S0950268824000566_r15","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16946"},{"key":"S0950268824000566_r8","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa307"},{"key":"S0950268824000566_r12","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1209-0"},{"key":"S0950268824000566_r14","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa349"},{"key":"S0950268824000566_r2","doi-asserted-by":"publisher","DOI":"10.1177\/0956462415624059"},{"key":"S0950268824000566_r10","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinmicnews.2014.12.001"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268824000566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T09:11:42Z","timestamp":1713863502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268824000566\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":19,"alternative-id":["S0950268824000566"],"URL":"https:\/\/doi.org\/10.1017\/s0950268824000566","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"\u00a9 The Author(s), 2024. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e63"}}