{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:13:12Z","timestamp":1787011992488,"version":"build-2736575974"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"unspecified","delay-in-days":275,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We aimed to estimate the secondary attack rate of mpox among UK household contacts and determine factors associated with transmission to inform public health management of contacts, during the global outbreak in 2022. Information was collected via NHS and public health services and included age, gender, place of residence, setting, and type of contact. Aggregate information was summarized for the UK. Record level data was combined for England, Wales and Northern Ireland, and multivariable logistic regression was used to determine factors associated with transmission. The secondary attack rate among UK household mpox contacts was 4% (60\/1\u00a0526). Sexual contact with the index case was associated with a 11-fold increase in adjusted odds of becoming a case in England, Wales, and Northern Ireland (95% CI 5.5\u201322,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Household contacts outside of London had increased odds compared to London residents (adjusted OR 2.9, 95%CI 1.6\u20135.4,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), while female contacts had reduced odds of becoming a case (aOR: 0.41, 95% CI: 0.15\u20130.95). We found a low overall secondary attack rate among household mpox contacts with strong evidence of increased transmission risk associated with sexual contact. This evidence will inform the risk assessment of contacts and support prioritization of those with close intimate contact for follow up.\n                  <\/jats:p>","DOI":"10.1017\/s0950268824000864","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T04:30:48Z","timestamp":1727843448000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":11,"title":["Mpox in UK households: estimating secondary attack rates and factors associated with transmission, May\u2013November 2022"],"prefix":"10.1017","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9157-3650","authenticated-orcid":false,"given":"Simon","family":"Packer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Patrzylas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2305-0898","authenticated-orcid":false,"given":"Rachel","family":"Merrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2679-7217","authenticated-orcid":false,"given":"Clare","family":"Sawyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McAuley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Crowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Findlater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obaghe","family":"Edeghere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"key":"S0950268824000864_r5","first-page":"465","article-title":"Human monkeypox: Secondary attack rates","volume":"66","author":"Jezek","year":"1988","journal-title":"Bulletin of the World Health Organization"},{"key":"S0950268824000864_r4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007791"},{"key":"S0950268824000864_r16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2207323"},{"key":"S0950268824000864_r12","unstructured":"[12] UK Health Security Agency (2022) Monkeypox: Contact tracing. Guidance. Available at https:\/\/www.gov.uk\/government\/publications\/monkeypox-contact-tracing (accessed 23 January 2023)."},{"key":"S0950268824000864_r8","first-page":"1","article-title":"Monkeypox outbreak predominantly affecting men who have sex with men, Madrid, Spain, 26 April to 16 June 2022","volume":"27","author":"Mart\u00ednez","year":"2022","journal-title":"Eurosurveillance European Centre for Disease Prevention and Control (ECDC)"},{"key":"S0950268824000864_r2","unstructured":"[2] World Health Organization (2022) Monkeypox, pp. 1\u20138. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/monkeypox."},{"key":"S0950268824000864_r6","first-page":"165","article-title":"Human monkeypox, 1970\u201379","volume":"58","author":"Breman","year":"1980","journal-title":"Bulletin of the World Health Organization"},{"key":"S0950268824000864_r19","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2022.306842"},{"key":"S0950268824000864_r11","unstructured":"[11] UK Health Security Agency (2022) Mpox (monkeypox): Case definitions. Guidance. Available at https:\/\/www.gov.uk\/guidance\/monkeypox-case-definitions#:~:text=Aprobablecaseis\u00a0defined,21daysbeforesymptomonset (accessed 23 January 2023)."},{"key":"S0950268824000864_r3","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00228-6"},{"key":"S0950268824000864_r9","first-page":"1","article-title":"Community transmission of monkeypox in the United Kingdom, April to May 2022","volume":"27","author":"Vivancos","year":"2022","journal-title":"Eurosurveillance European Centre for Disease Prevention and Control (ECDC)"},{"key":"S0950268824000864_r15","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28534"},{"key":"S0950268824000864_r18","unstructured":"[18] UK Health Security Agency (2022) Investigation into monkeypox outbreak in England: Technical briefing 8, London."},{"key":"S0950268824000864_r13","year":"2020"},{"key":"S0950268824000864_r14","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiad448"},{"key":"S0950268824000864_r7","unstructured":"[7] UK Health Security Agency (2022) Monkeypox outbreak: Epidemiological overview, 15 November 2022, pp. 1\u20136. https:\/\/www.gov.uk\/government\/publications\/monkeypox-outbreak-epidemiological-overview\/monkeypox-outbreak-epidemiological-overview-15-november-2022."},{"key":"S0950268824000864_r17","unstructured":"[17] UK Health Security Agency (2022) Monkeypox: Waiting for your vaccination. Mpox (monkeypox) vaccination resources. Available at https:\/\/www.gov.uk\/government\/publications\/monkeypox-vaccination-resources\/monkeypox-waiting-for-your-vaccination (accessed 30 June 2023)."},{"key":"S0950268824000864_r10","unstructured":"[10] UK Health Security Agency (2022) Mpox (monkeypox): diagnostic testing. Available at https:\/\/www.gov.uk\/guidance\/monkeypox-diagnostic-testing (accessed 23 January 2023)."},{"key":"S0950268824000864_r1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a011720"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268824000864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T04:30:53Z","timestamp":1727843453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268824000864\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":19,"alternative-id":["S0950268824000864"],"URL":"https:\/\/doi.org\/10.1017\/s0950268824000864","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"\u00a9 The Author(s), 2024. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e113"}}