{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:55:34Z","timestamp":1767858934045,"version":"3.49.0"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"unspecified","delay-in-days":277,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p><jats:italic>Streptococcus pneumoniae<\/jats:italic> serotype 35B, a non-vaccine type, is a major contributor to the increase in pneumococcal infection post-vaccination. We aimed to understand the mechanism of its spread by characterizing 35B. The serotype, type 1 pilus (T1P) positivity, and antimicrobial susceptibility of 319 isolates in 2018\u20132022 were analysed and compared with those of isolates in 2014\u20132017 to find the changes. 35B accounted for 40 (12.5%) isolates. T1P positivity was notably higher in 35B (87.5%) than in the other serotypes. To confirm the role of T1P, an adhesion factor, we compared adherence to A549 cells between <jats:italic>T1P<\/jats:italic>-positive 35B isolates and their <jats:italic>T1P<\/jats:italic>-deficient mutants, showing contribution of T1P to adherence. Penicillin-non-susceptible rate of 35B was 87.5%, and meropenem-resistant 35B rate was 35.0%, which increased from 14.5% of 2014\u20132017 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.009). Multilocus sequence typing was performed in 35B strains. Prevalence of clonal complex 558, harbouring <jats:italic>T1P<\/jats:italic> and exhibiting multidrug non-susceptibility, suggested the advantages of 35B in attachment and survival in the host. The emergence of ST156 isolates, <jats:italic>T1P<\/jats:italic>-positive and non-susceptible to \u03b2-lactams, has raised concern about expansion in Japan. The increase of serotype 35B in pneumococcal diseases might have occurred due to its predominant colonizing ability after the elimination of the vaccine-serotypes.<\/jats:p>","DOI":"10.1017\/s0950268824001031","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T06:15:29Z","timestamp":1728022529000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Bacteriological characteristics and changes of <i>Streptococcus pneumoniae<\/i> serotype 35B after vaccine implementation in Japan"],"prefix":"10.1017","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8716-8401","authenticated-orcid":false,"given":"Haruko","family":"Miyazaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michinaga","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Shibuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misako","family":"Takata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimiko","family":"Ubukata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitsugu","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Akeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"S0950268824001031_r18","unstructured":"[18] PubMLST. Public databases for molecular typing and microbial genome diversity. https:\/\/pubmlst.org\/spneumoniae\/ (accessed 24 January 2024)."},{"key":"S0950268824001031_r4","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2022.04.062"},{"key":"S0950268824001031_r9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05908.x"},{"key":"S0950268824001031_r28","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01083-22"},{"key":"S0950268824001031_r14","unstructured":"[14] CLSI M100 Performance standards for antimicrobial susceptibility testing, 33th edition. http:\/\/em100.edaptivedocs.net\/dashboard.aspx (accessed 24 January 2024)."},{"key":"S0950268824001031_r8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511017103"},{"key":"S0950268824001031_r7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2016.12.016"},{"key":"S0950268824001031_r19","unstructured":"[19] The Japanese IPD study group. 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