{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:09:53Z","timestamp":1771038593099,"version":"3.50.1"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"unspecified","delay-in-days":79,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>The study aims were to present in vitro susceptibilities of clinical isolates from Gram-negative bacteria bloodstream infections (GNBSI) collected in China. GNBSI isolates were collected from 18 tertiary hospitals in 7 regions of China from 2018 to 2020. Minimum inhibitory concentrations were assessed using a Trek Diagnostic System. Susceptibility was determined using CLSI broth microdilution, and breakpoints were interpreted using CLSI M100 (2021). A total of 1,815 GNBSI strains were collected, with <jats:italic>E. coli<\/jats:italic> (42.4%) and <jats:italic>Klebsiella pneumoniae<\/jats:italic> (28.6%) being the most prevalent species, followed by <jats:italic>P. aeruginosa<\/jats:italic> (6.7%). Susceptibility analyses revealed low susceptibilities (&lt;40%) of ESBL-producing <jats:italic>E. coli<\/jats:italic> and <jats:italic>K. pneumonia<\/jats:italic> to third-\/fourth-generation cephalosporins, monobactamases, and fluoroquinolones. High susceptibilities to colistin (95.0%) and amikacin (81.3%) were found for <jats:italic>K. pneumoniae<\/jats:italic>, while <jats:italic>Acinetobacter baumannii<\/jats:italic> exhibited a high susceptibility (99.2%) to colistin but a low susceptibility to other antimicrobials (&lt;27.5%). Isolates from ICUs displayed lower drug susceptibility rates of <jats:italic>K. pneumoniae<\/jats:italic> and <jats:italic>A. baumannii<\/jats:italic> than isolates from non-ICUs (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Carbapenem-resistant and ESBL-producing <jats:italic>K. pneumoniae<\/jats:italic> detection was different across regions (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). <jats:italic>E. coli<\/jats:italic> and <jats:italic>K. pneumoniae<\/jats:italic> were major contributors to GNBSI, while <jats:italic>A. baumannii<\/jats:italic> exhibited severe drug resistance in isolates obtained from ICU departments.<\/jats:p>","DOI":"10.1017\/s0950268824001286","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T07:29:40Z","timestamp":1742542180000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Antimicrobial susceptibility of gram-negative strains isolated from bloodstream infections in China: Results from the study for monitoring antimicrobial resistance trends (SMART) 2018\u20132020"],"prefix":"10.1017","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0814-1249","authenticated-orcid":false,"given":"Yili","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingjuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huayin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fupin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengcheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingchun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7487-3651","authenticated-orcid":false,"given":"Kang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"S0950268824001286_r33","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00425-4"},{"key":"S0950268824001286_r18","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2022.2093134"},{"key":"S0950268824001286_r29","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-019-0674-4"},{"key":"S0950268824001286_r32","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00399-6"},{"key":"S0950268824001286_r10","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S408927"},{"key":"S0950268824001286_r15","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2607"},{"key":"S0950268824001286_r11","volume-title":"23th Ed. 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e48"}}