{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:28:34Z","timestamp":1789061314872,"version":"build-2803163510"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"unspecified","delay-in-days":331,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["541003002"],"award-info":[{"award-number":["541003002"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Reducing antimicrobial use (AMU) in livestock may be one of the keys to limit the emergence of antimicrobial resistance (AMR) in bacterial populations, including zoonotic pathogens. This study assessed the temporal association between AMU in livestock and AMR among\n                    <jats:italic>Campylobacter<\/jats:italic>\n                    isolates from human infections in the Netherlands between 2004 \u2013 2020. Moreover, the associations between AMU and AMR in livestock and between AMR in livestock and AMR in human isolates were assessed. AMU and AMR data per antimicrobial class (tetracyclines, macrolides and fluoroquinolones) for\n                    <jats:italic>Campylobacter jejuni<\/jats:italic>\n                    and\n                    <jats:italic>Campylobacter coli<\/jats:italic>\n                    from poultry, cattle, and human patients were retrieved from national surveillance programs. Associations were assessed using logistic regression and the Spearman correlation test. Overall, there was an increasing trend in AMR among human\n                    <jats:italic>C. jejuni<\/jats:italic>\n                    \/\n                    <jats:italic>coli<\/jats:italic>\n                    isolates during the study period, which contrasted with a decreasing trend in livestock AMU. In addition, stable trends in AMR in broilers were observed. No significant associations were observed between AMU and AMR in domestically produced broilers. Moderate to strong positive correlations were found between the yearly prevalence of AMR in broiler and human isolates. Reducing AMU in Dutch livestock alone may therefore not be sufficient to tackle the growing problem of AMR in\n                    <jats:italic>Campylobacter<\/jats:italic>\n                    among human cases in the Netherlands. More insight is needed regarding the population genetics and the evolutionary processes involved in resistance and fitness among\n                    <jats:italic>Campylobacter.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1017\/s0950268824001511","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T09:47:18Z","timestamp":1732700838000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Reducing antimicrobial use in livestock alone may be not sufficient to reduce antimicrobial resistance among human\n                    <i>Campylobacter<\/i>\n                    infections: an ecological study in the Netherlands"],"prefix":"10.1017","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4880-760X","authenticated-orcid":false,"given":"Huifang","family":"Deng","sequence":"first","affiliation":[{"name":"Utrecht University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2532-5277","authenticated-orcid":false,"given":"Linda E.","family":"Chanam\u00e9 Pinedo","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5454-0350","authenticated-orcid":false,"given":"Anouk P.","family":"Meijs","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"Sanders","sequence":"additional","affiliation":[{"name":"The Netherlands Veterinary Medicines Authority"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees T.","family":"Veldman","sequence":"additional","affiliation":[{"name":"part of Wageningen University and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S. M.","family":"Brouwer","sequence":"additional","affiliation":[{"name":"part of Wageningen University and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wieke","family":"Altorf-van der Kuil","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Wullings","sequence":"additional","affiliation":[{"name":"Wageningen Food Safety Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ISIS-AR Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike J. C.","family":"van den Beld","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine C.","family":"de Greeff","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy M.","family":"Dierikx","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engeline","family":"van Duijkeren","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eelco","family":"Franz","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lapo","family":"Mughini-Gras","sequence":"additional","affiliation":[{"name":"Utrecht University"},{"name":"National Institute for Public Health and the Environment (RIVM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6408-3074","authenticated-orcid":false,"given":"Roan","family":"Pijnacker","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"S0950268824001511_r22","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01145"},{"key":"S0950268824001511_r36","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-animal-022516-022826"},{"key":"S0950268824001511_r17","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268803008392"},{"key":"S0950268824001511_r38","doi-asserted-by":"publisher","DOI":"10.2217\/17460913.4.2.189"},{"key":"S0950268824001511_r14","unstructured":"[14] Bondt, N , et al. (2012) Trends in veterinary antibiotic use in the Netherlands 2005\u20132011. Landbouw Economisch Instituut Wageningen UR. https:\/\/www.wur.nl\/nl\/publicatie-details.htm?publicationId=publication-way-343235333934."},{"key":"S0950268824001511_r34","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.763434"},{"key":"S0950268824001511_r25","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2022.109471"},{"key":"S0950268824001511_r28","doi-asserted-by":"publisher","DOI":"10.3201\/eid0902.020227"},{"key":"S0950268824001511_r2","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11131946"},{"key":"S0950268824001511_r40","doi-asserted-by":"publisher","DOI":"10.1086\/339195"},{"key":"S0950268824001511_r8","unstructured":"[8] European Medicines Agency. (2011) Trends in the sales of veterinary antimicrobial agents in nine European countries (2005\u20132009). 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(2020) Usage of antibiotics in agricultural livestock in the Netherlands in 2020: Trends and benchmarking of livestock farms and veterinarians. https:\/\/www.autoriteitdiergeneesmiddelen.nl\/en\/publications\/general-reports."},{"key":"S0950268824001511_r11","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2017.10.013"},{"key":"S0950268824001511_r23","doi-asserted-by":"publisher","DOI":"10.1016\/S2542-5196(23)00026-8"},{"key":"S0950268824001511_r35","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.1.71"},{"key":"S0950268824001511_r4","first-page":"e07867","article-title":"The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2020\/2021","volume":"21","year":"2023","journal-title":"EFSA Journal"},{"key":"S0950268824001511_r13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.09.039"},{"key":"S0950268824001511_r26","first-page":"e8442","article-title":"The European Union one health 2022 zoonoses report","volume":"21","year":"2023","journal-title":"EFSA Journal"},{"key":"S0950268824001511_r31","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2016.05.069"},{"key":"#cr-split#-S0950268824001511_r16.1","unstructured":"[16] European Commission. 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e148"}}