{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:26:04Z","timestamp":1788272764845,"version":"build-2803163510"},"reference-count":46,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"unspecified","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hand, foot and mouth disease (HFMD) is a contagious communicable disease, with a high incidence in children aged under 10\u00a0years. It is a mainly self-limiting disease but can also cause serious neurological or cardiopulmonary complications in some cases, which can lead to death. Little is known about the burden of HMFD on primary care health care services in the UK. The aim of this work was to describe trends in general practitioner (GP) consultations for HFMD in England from January 2017 to December 2022 using a syndromic surveillance network of GPs. Daily GP consultations for HFMD in England were extracted from 1 January 2017 to 31 December 2022. Mean weekly consultation rates per 100,000 population and 95% confidence intervals (CI) were calculated. Consultation rates and rate ratios (RR) were calculated by age group and sex. During the study period, the mean weekly consultation rate for HFMD (per 100,000 registered GP patients) was 1.53 (range of 0.27 to 2.47). In England, children aged 1\u20134\u00a0years old accounted for the largest affected population followed by children &lt;1\u00a0years old. We observed a seasonal pattern of HFMD incidence during the non-COVID years, with a seasonal peak of mean weekly rates between months of September and December. HFMD is typically diagnosed clinically rather than through laboratory sampling. Therefore, the ability to look at the daily HFMD consultation rates provides an excellent epidemiological overview on disease trends. The use of a novel GP-in-hours surveillance system allowed a unique epidemiological insight into the recent trends of general practitioner consultations for HFMD. We demonstrate a male predominance of cases, the impact of the non-pharmaceutical interventions during the COVID-19 pandemic, and a change in the week in which the peak number of cases happens post-pandemic.<\/jats:p>","DOI":"10.1017\/s095026882400181x","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T01:39:26Z","timestamp":1736732366000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Trends in general practitioner consultations for hand foot and mouth disease in England between 2017 and 2022"],"prefix":"10.1017","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2623-2120","authenticated-orcid":false,"given":"Natalia G.","family":"Bednarska","sequence":"first","affiliation":[{"name":"UK Health Security Agency"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1066-5175","authenticated-orcid":false,"given":"Sue","family":"Smith","sequence":"additional","affiliation":[{"name":"UK Health Security Agency"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9690-6493","authenticated-orcid":false,"given":"Megan","family":"Bardsley","sequence":"additional","affiliation":[{"name":"UK Health Security Agency"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Loveridge","sequence":"additional","affiliation":[{"name":"UK Health Security Agency"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4792-8995","authenticated-orcid":false,"given":"Rachel","family":"Byford","sequence":"additional","affiliation":[{"name":"University of Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8630-1378","authenticated-orcid":false,"given":"William H","family":"Elson","sequence":"additional","affiliation":[{"name":"University of Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3664-2983","authenticated-orcid":false,"given":"Helen E.","family":"Hughes","sequence":"additional","affiliation":[{"name":"UK Health Security Agency"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8553-2641","authenticated-orcid":false,"given":"Simon","family":"de Lusignan","sequence":"additional","affiliation":[{"name":"University of Oxford"},{"name":"Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-4786","authenticated-orcid":false,"given":"Daniel","family":"Todkill","sequence":"additional","affiliation":[{"name":"UK Health Security Agency"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6414-3065","authenticated-orcid":false,"given":"Alex J.","family":"Elliot","sequence":"additional","affiliation":[{"name":"UK Health Security Agency"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"S095026882400181X_r43","doi-asserted-by":"publisher","DOI":"10.3201\/eid2404.171298"},{"key":"S095026882400181X_r18","doi-asserted-by":"publisher","DOI":"10.2196\/19773"},{"key":"S095026882400181X_r21","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-08961-6"},{"key":"S095026882400181X_r19","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp23X734289"},{"key":"S095026882400181X_r8","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2017-000442"},{"key":"S095026882400181X_r6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16705-7"},{"key":"S095026882400181X_r20","first-page":"65","article-title":"Codes, classifications, terminologies and nomenclatures: Definition, development and application in practice","volume":"13","author":"de Lusignan","year":"2005","journal-title":"Informatics in Primary Care"},{"key":"S095026882400181X_r35","doi-asserted-by":"publisher","DOI":"10.2196\/39141"},{"key":"S095026882400181X_r27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0287539"},{"key":"S095026882400181X_r17","doi-asserted-by":"publisher","DOI":"10.3390\/v15112163"},{"key":"S095026882400181X_r28","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8561(02)00022-X"},{"key":"S095026882400181X_r10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201726"},{"key":"S095026882400181X_r34","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-12117-5"},{"key":"S095026882400181X_r3","doi-asserted-by":"publisher","DOI":"10.1057\/s41271-017-0066-z"},{"key":"S095026882400181X_r40","doi-asserted-by":"publisher","DOI":"10.3201\/eid1509.090438"},{"key":"S095026882400181X_r46","unstructured":"[46] NHS. 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