{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:15:19Z","timestamp":1787681719879,"version":"build-2784847793"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"unspecified","delay-in-days":197,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Mosquito-borne California serogroup orthobunyaviruses Inkoo (INKV) and Chatanga (CHATV) are known to be endemic in Finland with a high seroprevalence. We developed a novel multiplexed reverse transcription quantitative polymerase chain reaction method for discriminating between the INKV and CHATV. This assay was used along with traditional serological tests to study a set of summertime patients during the years 2021, 2023, and 2024 to assess the epidemiology and prevalence of acute INKV and CHATV infections in Finland. Altogether, 1470 samples were screened, and there were 16 patients who had an acute infection based on serological findings and\/or nucleic acid test. The orthobunyavirus-IgG seroprevalences were 18% (2021), 20% (2023), and 30% (2024), being lower than that in studies from 20\u00a0years ago. Neutralization tests were carried out, and all but one acute case had more than four-fold higher titre to INVK vs. CHATV, indicating specificity to INKV infection. The results suggest that epidemiology has changed from previous studies, and INKV should be considered a causative agent of summertime infections in Finland. The symptom diversity in mild disease outcomes should be studied to guide orthobunyavirus recognition by clinicians. The use of molecular assay discriminating INKV and CHATV aids in understanding disease associations.<\/jats:p>","DOI":"10.1017\/s0950268825100289","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T08:14:19Z","timestamp":1752740059000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Detection of California Serogroup Orthobunyavirus antibodies and Inkoo virus RNA in patients, Finland"],"prefix":"10.1017","volume":"153","author":[{"given":"Eveliina","family":"Ekstr\u00f6m","sequence":"first","affiliation":[{"name":"Helsinki University Hospital"},{"name":"University of Helsinki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katariina","family":"Kaansalo","sequence":"additional","affiliation":[{"name":"University of Helsinki"},{"name":"University of Helsinki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maija T.","family":"Suvanto","sequence":"additional","affiliation":[{"name":"University of Helsinki"},{"name":"University of Helsinki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Utriainen","sequence":"additional","affiliation":[{"name":"University of Helsinki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niina","family":"Putkuri","sequence":"additional","affiliation":[{"name":"Finnish Red Cross, Blood Service"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Vapalahti","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital"},{"name":"University of Helsinki"},{"name":"University of Helsinki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannimari","family":"Kallio-Kokko","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital"},{"name":"University of Helsinki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eili","family":"Huhtamo","sequence":"additional","affiliation":[{"name":"University of Helsinki"},{"name":"University of Helsinki"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3713-8110","authenticated-orcid":false,"given":"Anne J.","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital"},{"name":"University of 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