{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:26:40Z","timestamp":1759883200614,"version":"build-2065373602"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"unspecified","delay-in-days":258,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>A predictive column chart was developed to assess the risk of primary liver cancer (PLC) in hepatitis B patients. Data from 107 PLC patients and 107 controls were used as the training set, with 92 patients as the validation set. An additional 446 patients from other hospitals, including 15 with PLC, formed the external validation group. Multivariate logistic regression identified gender, BMI, alcohol consumption, diabetes, family history of liver cancer, cirrhosis, and HBV DNA load as independent risk factors. The model showed strong discrimination with AUCs of 0.882 and 0.859 in the training and validation sets, respectively, and good calibration (Hosmer\u2013Lemeshow \u03c7\u00b2 = 2.648, P = 0.954; \u03c7\u00b2 = 4.117, P = 0.846). Decision curve analysis (DCA) confirmed clinical benefit within a risk threshold of 0.07\u20130.95. In the external validation group, the model maintained discrimination (AUC = 0.863) and calibration (Hosmer\u2013Lemeshow \u03c7\u00b2 = 7.999, P = 0.434), with DCA showing net benefit across 0.14\u20130.95. These results indicate the column chart is a reliable tool for PLC risk prediction in hepatitis B patients.<\/jats:p>","DOI":"10.1017\/s0950268825100538","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:58:43Z","timestamp":1758009523000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of influencing factors of concurrent primary liver cancer in hepatitis B patients and construction of column chart prediction model"],"prefix":"10.1017","volume":"153","author":[{"given":"Qunmei","family":"Cao","sequence":"first","affiliation":[{"name":"Ganzhou People\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Ganzhou People\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changlong","family":"Wen","sequence":"additional","affiliation":[{"name":"Ganzhou People\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7844-500X","authenticated-orcid":false,"given":"Qinglan","family":"Li","sequence":"additional","affiliation":[{"name":"Ganzhou People\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"S0950268825100538_r17","doi-asserted-by":"publisher","DOI":"10.1007\/s44197-024-00237-1"},{"key":"S0950268825100538_r16","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13452"},{"key":"S0950268825100538_r12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI176345"},{"key":"S0950268825100538_r9","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00825-3"},{"key":"S0950268825100538_r7","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"S0950268825100538_r1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33313"},{"key":"S0950268825100538_r21","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-051946"},{"key":"S0950268825100538_r6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i42.9279"},{"key":"S0950268825100538_r11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2022.11.001"},{"key":"S0950268825100538_r5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.09.011"},{"key":"S0950268825100538_r2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34418"},{"key":"S0950268825100538_r4","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15997"},{"key":"S0950268825100538_r13","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16548"},{"key":"S0950268825100538_r19","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00688-6"},{"key":"S0950268825100538_r22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.02.040"},{"key":"S0950268825100538_r14","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2020.0176"},{"key":"S0950268825100538_r10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2022.10.009"},{"key":"S0950268825100538_r20","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1913"},{"key":"S0950268825100538_r8","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28980"},{"key":"S0950268825100538_r18","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1398968"},{"key":"S0950268825100538_r3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-59211-3"},{"key":"S0950268825100538_r15","article-title":"Diabetes mellitus impacts on the performance of hepatocellular carcinoma risk scores in chronic hepatitis B patients","volume":"21","author":"Yip","year":"2023","journal-title":"Clinical Gastroenterology and Hepatology\u00a0: the Official Clinical Practice Journal of the American Gastroenterological Association"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268825100538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T15:44:10Z","timestamp":1759851850000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268825100538\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":22,"alternative-id":["S0950268825100538"],"URL":"https:\/\/doi.org\/10.1017\/s0950268825100538","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"type":"print","value":"0950-2688"},{"type":"electronic","value":"1469-4409"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e111"}}