{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:10:27Z","timestamp":1792131027380,"version":"4.4.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"unspecified","delay-in-days":294,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This nationwide retrospective study in Japan aimed to identify risk factors and diagnostic indicators for congenital syphilis (CS) and improve diagnostic accuracy. Data were collected from 230 pregnant women diagnosed with syphilis and their infants between 2015 and 2024. Of these, 49 infants were diagnosed with definite or highly probable CS, while 73 infants with excluded CS served as the control group. Multivariable logistic regression analysis revealed two significant risk factors for CS: maternal treatment not completed more than 4\u00a0weeks before delivery (odds ratio [OR]: 7.20; 95% confidence interval [CI]: 1.38\u201337.56; p\u00a0=\u00a00.02) and elevated total IgM levels in the infant (&gt;20\u00a0mg\/dL) (OR: 65.31; 95% CI: 4.53\u2013941.39; p\u00a0=\u00a00.002). When using infant rapid plasma reagin (RPR) \u22651 as a diagnostic indicator, sensitivity was 93.8% (n\u00a0=\u00a048). In contrast, the infant-to-mother RPR ratio\u00a0\u22651 showed a lower sensitivity of 34.3%, with fewer cases available for analysis (n\u00a0=\u00a035) due to limited maternal data. These findings indicate that delayed maternal treatment and high total IgM levels in the infant are significant risk factors, while the infant\u2019s RPR titre serves as a useful diagnostic indicator for CS.<\/jats:p>","DOI":"10.1017\/s0950268825100629","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T08:25:30Z","timestamp":1761121530000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Risk factors and diagnostic indicators for congenital syphilis: a Nationwide retrospective survey"],"prefix":"10.1017","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5926-2713","authenticated-orcid":false,"given":"Hiroyuki","family":"Shimizu","sequence":"first","affiliation":[{"name":"Fujisawa City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munehiro","family":"Furuichi","sequence":"additional","affiliation":[{"name":"Keio University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3659-865X","authenticated-orcid":false,"given":"Noriko","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Chiba University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Ito","sequence":"additional","affiliation":[{"name":"Aichi Children\u2019s Health and Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Funaki","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Ito","sequence":"additional","affiliation":[{"name":"Aichi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Mori","sequence":"additional","affiliation":[{"name":"St Marianna University School of Medicine"},{"name":"Institute of Science Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Moriuchi","sequence":"additional","affiliation":[{"name":"Nagasaki University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9566-201X","authenticated-orcid":false,"given":"Takuya","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6291-7186","authenticated-orcid":false,"given":"Masayoshi","family":"Shinjoh","sequence":"additional","affiliation":[{"name":"Keio University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,10,22]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268825100629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T08:04:57Z","timestamp":1762243497000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268825100629\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"alternative-id":["S0950268825100629"],"URL":"https:\/\/doi.org\/10.1017\/s0950268825100629","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e127"}}