{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T12:29:08Z","timestamp":1766147348224,"version":"3.48.0"},"reference-count":63,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"unspecified","delay-in-days":352,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81950410639,82304246"],"award-info":[{"award-number":["81950410639,82304246"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["20200344"],"award-info":[{"award-number":["20200344"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2023NSCQ-MSX0198"],"award-info":[{"award-number":["CSTB2023NSCQ-MSX0198"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2304900,2022YFC2505100"],"award-info":[{"award-number":["2022YFC2304900,2022YFC2505100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study assessed the impact and cost-effectiveness of pre-exposure prophylaxis (PrEP) in reducing HIV infections and HIV-related deaths among four key populations in China: men who have sex with men (MSM). Female sex workers (FSW), people who inject drugs (PWID), and HIV-negative partners of serodiscordant couples (SDC). Decision-analytic Markov models simulated HIV transmission and progression in cohorts of 100,000 adults over 40 years under three strategies: no PrEP, daily oral PrEP, and on-demand oral PrEP evaluated nationaly and high-incidence provinces. Cost-effectiveness was measured using a willingness-to-pay threshold of US$37,653 per QALY. Across all populations, on-demand PrEP was the most cost-effective strategy. Among MSM, it was cost-effective both nationwide (ICER: $4,554\/QALY) and in high-incidence provinces (ICER: $1,045-2,129\/QALY), reducing new infections by 24.7%. Daily PrEP was also const-effective for MSM nationally and prevented 19.9% of infections. For FSW, on-demand PrEP was cost-effective in high-incidence provinces (ICER: $25,399-37,045\/QALY), reducing infections by 21.8%-22.5%. For PWID, it was cost-effective in high-incidence provinces (ICER: $10,361-29,560\/QALY), reducing infections by 15.5%-17.9%. For HIV-negative partners of SDC, on-demand PrEP was cost-effective both nationally and in high-incidence provinces, reducing infections by 24.0%. Overall, on-demand PrEP offers substantial health and economic benefits, particularly for HIV-negative partners of SDC and high-incidence regions.<\/jats:p>","DOI":"10.1017\/s095026882510068x","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T12:25:51Z","timestamp":1766147151000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological impacts and cost-effectiveness of daily and on-demand oral pre-exposure prophylaxis among key HIV populations in China: An economic evaluation"],"prefix":"10.1017","volume":"153","author":[{"given":"Shu","family":"Su","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Chongqing Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhang","family":"Wei","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University Health Science Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Dong","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Sun","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxuan","family":"Li","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University Health Science Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University Health Science Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingxian","family":"Song","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Chongqing Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0839-4548","authenticated-orcid":false,"given":"Zunyou","family":"Wu","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shenzhen Hospital of Southern Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2343-084X","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University Health Science Center"},{"name":"Melbourne Sexual Health Centre"},{"name":"The Second Affiliated Hospital of Xi\u2019an Jiaotong University"},{"name":"Monash University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"S095026882510068X_r6","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.03.020"},{"key":"S095026882510068X_r17","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-019-00471-4"},{"key":"S095026882510068X_r43","first-page":"673","article-title":"Methods for the economic evaluation of health care interventions for priority setting in the health system: An update from WHO CHOICE","volume":"10","author":"Bertram","year":"2021","journal-title":"International Journal of Health Policy and Management"},{"key":"S095026882510068X_r42","doi-asserted-by":"publisher","DOI":"10.35772\/ghm.2024.01030"},{"key":"S095026882510068X_r22","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2021.1896661"},{"key":"S095026882510068X_r61","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.48782"},{"key":"S095026882510068X_r63","doi-asserted-by":"publisher","DOI":"10.2196\/46767"},{"key":"S095026882510068X_r5","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(22)00309-5"},{"key":"S095026882510068X_r45","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-018-0672-z"},{"key":"S095026882510068X_r25","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2022.100462"},{"key":"S095026882510068X_r4","unstructured":"[4] UNAIDS. 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e139"}}