{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:22:41Z","timestamp":1793305361048,"version":"4.5.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"unspecified","delay-in-days":306,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Candida auris<\/jats:italic>\n                    has emerged as a major nosocomial pathogen due to multidrug resistance (MDR), outbreak potential, and high mortality in critically ill patients. Identifying risk factors for\n                    <jats:italic>C. auris<\/jats:italic>\n                    candidemia is essential for prevention and infection control. In this single-centre, retrospective case\u2013control study, we analysed adults with\n                    <jats:italic>C. auris<\/jats:italic>\n                    candidemia (n\u00a0=\u00a052) and matched controls (n\u00a0=\u00a0104) hospitalized between February 2019 and October 2024. Matching was based on hospital unit and blood culture timing. Clinical and epidemiological variables were compared, and multivariate logistic regression identified independent risk factors. Antifungal susceptibility and 14- and 28-day all-cause mortality were evaluated as secondary outcomes. Independent risk factors included recent hospitalization (odds ratio (OR): 7.93), prolonged hospital stay (OR: 1.01), prior broad-spectrum antibiotic use (OR: 46.20), central venous catheter (CVC) (OR: 3.88), sepsis (OR: 9.43), and high Candida Colonization Index (OR: 14.10). All-cause mortality at 14 and 28\u00a0days was 30.8% and 46.2%, respectively. Fluconazole resistance was 96%, while 8.7% of isolates were pandrug resistant.\n                    <jats:italic>C. auris<\/jats:italic>\n                    candidemia represents a serious clinical challenge with substantial mortality and modifiable risk factors. Strengthening antimicrobial stewardship, colonization surveillance, and early recognition in high-risk patients may reduce its impact.\n                  <\/jats:p>","DOI":"10.1017\/s0950268825100721","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T07:57:18Z","timestamp":1762156638000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Risk factors associated with\n                    <i>Candida auris<\/i>\n                    Candidemia: A single-centre retrospective case\u2013control study"],"prefix":"10.1017","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4759-0066","authenticated-orcid":false,"given":"Ayse","family":"Kaya","sequence":"first","affiliation":[{"name":"Ankara Yildirim Beyazit University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Eser","sequence":"additional","affiliation":[{"name":"Ankara Yildirim Beyazit University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Hasanoglu","sequence":"additional","affiliation":[{"name":"Ankara Yildirim Beyazit University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bircan","family":"Kayaaslan","sequence":"additional","affiliation":[{"name":"Ankara Yildirim Beyazit University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Ankara City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse Yasemin","family":"Tezer Tekce","sequence":"additional","affiliation":[{"name":"Ankara Bilkent City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bedia","family":"Dinc","sequence":"additional","affiliation":[{"name":"Ankara City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fisun","family":"Kirca","sequence":"additional","affiliation":[{"name":"Ankara Bilkent City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice Rahmet","family":"Guner","sequence":"additional","affiliation":[{"name":"Ankara Yildirim Beyazit University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,11,3]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268825100721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:12:38Z","timestamp":1763367158000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268825100721\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"alternative-id":["S0950268825100721"],"URL":"https:\/\/doi.org\/10.1017\/s0950268825100721","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e131"}}