{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:59:30Z","timestamp":1785405570239,"version":"3.56.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"unspecified","delay-in-days":161,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We aimed to comprehensively assess\n                    <jats:italic>Stenotrophomonas maltophilia<\/jats:italic>\n                    infections, examining their incidence and clinical and microbiological characteristics in a tertiary hospital between 2021 and 2023. Primary outcomes were 30-day mortality and desirability-of-outcome ranking (DOOR).\n                    <jats:italic>S. maltophilia<\/jats:italic>\n                    incidence rose from 0.38 in 2017 to 2.66 cases\/1000 patient-days in 2023, correlated with carbapenem consumption (rho\u00a0=\u00a00.90,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.04). The cohort included 101 patients (median age of 61\u00a0years, IQR 43\u201371); 63% were male patients, 91% admitted in ICU, predominantly with lower respiratory tract infections (75%). Difficult-to-treat resistance (DTR) was identified in 14% of the isolates and associated with previous trimethoprim\u2013sulfamethoxazole (TMP\u2013SMX) use (aOR 23.15, 95% CI 3.67\u2013145.77). Thirty-day mortality was 25% and associated with invasive mechanical ventilation (aOR 5.80, 95% CI 1.03\u201332.63), while appropriate definitive therapy was protective (aOR 0.01, 95% CI &lt;0.01\u20130.16). Worse DOOR outcomes were associated with levofloxacin-resistant isolates (69.3%, CI 55.9%\u201380.9%) and inappropriate definitive treatment (81.1%, 95% CI 68.2%\u201390.8%). Overall,\n                    <jats:italic>S. maltophilia<\/jats:italic>\n                    has emerged as a relevant carbapenem-resistant gram-negative bacteria, with a high frequency of DTR phenotypes associated with previous TMP\u2013SMX exposure. Appropriate therapy and levofloxacin susceptibility were linked to better outcomes.\n                  <\/jats:p>","DOI":"10.1017\/s0950268826101708","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T03:18:27Z","timestamp":1781147907000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors and outcomes associated with difficult-to-treat resistance in\n                    <i>Stenotrophomonas maltophilia<\/i>\n                    : A clinical and microbiological hospital-based cohort study"],"prefix":"10.1017","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8867-1970","authenticated-orcid":false,"given":"Patricio","family":"Ross","sequence":"first","affiliation":[{"name":"Pontificia Universidad Catolica de Chile"},{"name":"Red de Salud UC Christus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasim","family":"Allel","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Catolica de Chile"},{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"G\u00e1ndara","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Catolica de Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Peralta","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01qe7f394","id-type":"ROR","asserted-by":"publisher"}],"name":"Servicio de Salud Arica y Parinacota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Caro","sequence":"additional","affiliation":[{"name":"Red de Salud UC Christus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Castillo","sequence":"additional","affiliation":[{"name":"Red de Salud UC Christus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javiera","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Catolica de Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Miles","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Catolica de Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Amstein","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Catolica de Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Red de Salud UC Christus"},{"name":"Pontificia Universidad Catolica de Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Labarca","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Catolica de Chile"},{"name":"Red de Salud UC Christus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,6,11]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268826101708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T08:53:06Z","timestamp":1783500786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268826101708\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"alternative-id":["S0950268826101708"],"URL":"https:\/\/doi.org\/10.1017\/s0950268826101708","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e90"}}