{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:09:54Z","timestamp":1788865794641,"version":"build-2803163510"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"unspecified","delay-in-days":179,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this proof-of-concept study, we explored the potential of structured general practice data for early signal detection, to enhance pandemic preparedness. We used electronic health record data from the Family Medicine Network (FaMe-Net) in the Netherlands between 2014 and 2024. Descriptive evaluation with surveillance attributes was performed, and the Farrington flexible method was used to construct an alert threshold for respiratory, gastroenteritis, rash, infectious conjunctivitis, and fever syndromes. Alert signals were generated, indicating when the observed weekly count exceeded the threshold. This data registry performed adequately for most surveillance attributes. We analysed 634708 diagnostic codes and 9 infectious disease syndromes in the data registry. In 154\u00a0weeks, the number of alert signals ranged from 3 to 20. We found similarities and variations in the number of alert signals between infectious syndrome definitions within the different data types. Structured general practice data showed potential for surveillance and early signal detection of infectious diseases because it performed well on most surveillance attributes and weekly counts of infectious disease syndromes led to the generation of alert signals. Further validation of these alert signals is needed, to underpin their early warning potential for timely public health action.<\/jats:p>","DOI":"10.1017\/s0950268826101800","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:30:51Z","timestamp":1782693051000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Pandemic preparedness: Potential of routine general practice data for infectious disease early signal detection"],"prefix":"10.1017","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9849-4031","authenticated-orcid":false,"given":"Jessica M.","family":"Aguilar Diaz","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05wg1m734","id-type":"ROR","asserted-by":"publisher"}],"name":"Radboud University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia H. M.","family":"van Jaarsveld","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05wg1m734","id-type":"ROR","asserted-by":"publisher"}],"name":"Radboud University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alo\u00efs","family":"Kessener","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05wg1m734","id-type":"ROR","asserted-by":"publisher"}],"name":"Radboud University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Uijen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05wg1m734","id-type":"ROR","asserted-by":"publisher"}],"name":"Radboud University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Giardina","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05wg1m734","id-type":"ROR","asserted-by":"publisher"}],"name":"Radboud University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim C.","family":"Olde Hartman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05wg1m734","id-type":"ROR","asserted-by":"publisher"}],"name":"Radboud University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn F. H.","family":"Raven","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05wg1m734","id-type":"ROR","asserted-by":"publisher"}],"name":"Radboud University Medical Center"},{"name":"Public Health Service region Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aura","family":"Timen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05wg1m734","id-type":"ROR","asserted-by":"publisher"}],"name":"Radboud University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,6,29]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268826101800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:36:04Z","timestamp":1788863764000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268826101800\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"alternative-id":["S0950268826101800"],"URL":"https:\/\/doi.org\/10.1017\/s0950268826101800","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press or the rights holder(s) must be obtained prior to any commercial use and\/or adaptation of the article.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e113"}}