{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:51:36Z","timestamp":1791975096363,"version":"4.4.0"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"unspecified","delay-in-days":286,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100019533","name":"Moderna","doi-asserted-by":"publisher","award":["CHAIR MODERNA-URJC"],"award-info":[{"award-number":["CHAIR MODERNA-URJC"]}],"id":[{"id":"10.13039\/100019533","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This observational descriptive study analyses the hospital burden of respiratory syncytial virus (RSV) among adults in Spain using the Minimum Basic Data Set (MBDS) from the Spanish National Hospital Data Surveillance System. Hospital admissions of adults diagnosed with non-bronchiolitis RSV infection between 2016 and 2023 were identified using ICD-10-CM codes. A total of 288,297 RSV-related hospitalizations were recorded, with a mean patient age of 76.18\u00a0years. The overall hospitalization rate was 92.43 per 100,000 inhabitants, and the mortality rate was 5.32 per 100,000. The most common severe comorbidities at admission were congestive heart failure, diabetes, and chronic obstructive pulmonary disease. Patients aged over 65\u00a0years had a significantly higher risk of in-hospital mortality (OR 1.78; 95% CI: 1.64\u20131.93) compared to those aged 40\u201364\u00a0years, increasing to 2.22 (95% CI: 2.05\u20132.40) in the presence of at least one severe comorbidity. Male sex was also associated with increased mortality risk (OR 1.24; 95% CI: 1.20\u20131.28). In conclusion, RSV represents a substantial cause of hospitalization and mortality among adults in Spain, particularly in patients over 60\u00a0years, males, and those with underlying comorbidities.<\/jats:p>","DOI":"10.1017\/s0950268826102076","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:22:55Z","timestamp":1791973375000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Burden of RSV hospital disease and its comorbidities in adults in Spain (2016\u20132023)"],"prefix":"10.1017","volume":"154","author":[{"given":"Fernando","family":"Trigo","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01v5cv687","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidad Rey Juan Carlos"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-7188","authenticated-orcid":false,"given":"Jose Maria","family":"Guillen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01v5cv687","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidad Rey Juan Carlos Facultad de Ciencias de la Salud"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Hernandez-Barrera","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01v5cv687","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidad Rey Juan Carlos - Campus de Alcorc\u00f3n"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Gil","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01v5cv687","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidad Rey Juan Carlos - Campus de Alcorc\u00f3n"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Gil","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01v5cv687","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidad Rey Juan Carlos - Campus de Alcorc\u00f3n"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"S0950268826102076_r17","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.04.011"},{"key":"S0950268826102076_r28","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab491"},{"key":"S0950268826102076_r25","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12643"},{"key":"S0950268826102076_r9","unstructured":"[9] Instituto de Salud Carlos III 2021 Informe de Vigilancia de la Infecci\u00f3n Respiratoria Aguda en Espa\u00f1a. Temporada 2020\u20132021 [Informe de vigilancia] [Internet]. Madrid: Instituto de Salud Carlos III. https:\/\/cne.isciii.es\/documents\/d\/cne\/informe_vigilancia_ira_4020-3921_16nov2021-pdf."},{"key":"S0950268826102076_r19","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab595"},{"key":"S0950268826102076_r8","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq433"},{"key":"S0950268826102076_r14","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac434"},{"key":"S0950268826102076_r13","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.44756"},{"key":"S0950268826102076_r5","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz059"},{"key":"S0950268826102076_r20","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-024-01021-1"},{"key":"S0950268826102076_r26","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix196"},{"key":"S0950268826102076_r30","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwae016"},{"key":"S0950268826102076_r4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182321"},{"key":"S0950268826102076_r21","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0105-2022"},{"key":"S0950268826102076_r23","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12665"},{"key":"S0950268826102076_r2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200522070-00004"},{"key":"S0950268826102076_r15","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2025.30.25.2400624"},{"key":"S0950268826102076_r6","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiae171"},{"key":"S0950268826102076_r3","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy056"},{"key":"S0950268826102076_r16","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-023-00792-3"},{"key":"S0950268826102076_r22","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiad415"},{"key":"S0950268826102076_r27","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192214680"},{"key":"S0950268826102076_r12","doi-asserted-by":"publisher","DOI":"10.4321\/s2173-92772024000100003"},{"key":"S0950268826102076_r24","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw270"},{"key":"S0950268826102076_r29","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.11764"},{"key":"S0950268826102076_r18","doi-asserted-by":"publisher","DOI":"10.3390\/geriatrics9060145"},{"key":"S0950268826102076_r31","unstructured":"[31] SIVAMIN. Informe de evoluci\u00f3n de coberturas de vacunaci\u00f3n por vacuna [Internet]. [cited 2026 Mar 15]. https:\/\/pestadistico.inteligenciadegestion.sanidad.gob.es\/publicoSNS\/I\/sivamin\/informe-de-evolucion-de-coberturas-de-vacunacion-por-vacuna."},{"key":"S0950268826102076_r7","unstructured":"[7] Real Decreto 69\/2015, de 6 de febrero, por el que se regula el Registro de Actividad de Atenci\u00f3n Sanitaria Especializada. 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Madrid: Instituto de Salud Carlos III. https:\/\/cne.isciii.es\/documents\/d\/cne\/informe-sivira-de-vigilancia-de-gripe-covid-19-y-vrs_temporada-2021-22_v14112022."}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268826102076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:22:59Z","timestamp":1791973379000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268826102076\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":32,"alternative-id":["S0950268826102076"],"URL":"https:\/\/doi.org\/10.1017\/s0950268826102076","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. 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