{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:40:03Z","timestamp":1790178003593,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[1997,2,1]],"date-time":"1997-02-01T00:00:00Z","timestamp":854755200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1997,2]]},"abstract":"<jats:p>In order to evaluate prophylaxis and therapy for individuals \n\ninfected with pathogens by the airborne route, we have designed and \n\nbuilt a simple apparatus in which small laboratory animals may be \n\nexposed to aerosols of infectious microorganisms. Animals are kept in \n\na chamber closed by a HEPA filter and exposed to the pathogen \n\naerosolized using a Collison nebulizer. Air in the exposure chamber \n\nmay be sampled to show that the infectious agent is present but the \n\ndose of agent must be expressed as 50% effective doses determined by \n\ntitration. An effective dose may be defined by whatever criteria are \n\nchosen to judge disease. Using this apparatus we have shown that St \n\nLouis encephalitis (SLE) virus is infectious for mice by the airborne \n\nroute. These data support the idea that there may be significant \n\nhazard to personnel exposed to aerosols of infectious SLE after a \n\nlaboratory accident.<\/jats:p>","DOI":"10.1017\/s0950268896007157","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:23:42Z","timestamp":1027776222000},"page":"71-75","source":"Crossref","is-referenced-by-count":30,"title":["A simple device for the exposure of animals to infectious \n\nmicroorganisms by the airborne route"],"prefix":"10.1017","volume":"118","author":[{"given":"R. J.","family":"PHILLPOTTS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J. G.","family":"BROOKS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. S.","family":"COX","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1997,2,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268896007157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T19:09:48Z","timestamp":1557688188000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268896007157\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["S0950268896007157"],"URL":"https:\/\/doi.org\/10.1017\/s0950268896007157","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,2]]}}}