{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:45:16Z","timestamp":1786999516428,"version":"build-2736575974"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[1997,8,1]],"date-time":"1997-08-01T00:00:00Z","timestamp":870393600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:p>\n                    In 1996 Japan had a big outbreak of enterohaemorrhagic\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (EHEC) O157[ratio   ]H7, \nespecially in Osaka prefecture where about 6000 patients (mainly \nschoolchildren) suffered from \ndiarrhoea, haemorrhagic colitis and haemolytic uraemic syndrome (HUS) due to EHEC \ninfection via school lunch. Our survey of doctors who took care \nof those patients showed that \nmost patients had received antibiotics, especially fosfomycin which \ncomprised 84% of the \nprescribed treatment. Since the administration of antibiotics for \nEHEC infection is under \ndiscussion, we analysed the effect of fosfomycin on production\/release \nof verotoxins (VTs). \nAddition of fosfomycin into EHEC culture in CAYE broth at 2 and 5 h after start of \nincubation caused marked increase of VT1 release. This observation \nwarns of the possibility of \nfosfomycin treatment making the disease worse.\n                  <\/jats:p>","DOI":"10.1017\/s0950268897007541","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:23:42Z","timestamp":1027761822000},"page":"101-103","source":"Crossref","is-referenced-by-count":23,"title":["SHORT PAPER The stimulating effect of fosfomycin, an antibiotic in common \nuse in Japan, on the production\/release of verotoxin-1 from \nenterohaemorrhagic\n                    <i>Escherichia coli<\/i>\n                    O157[ratio   ]H7\n                    <i>in vitro<\/i>"],"prefix":"10.1017","volume":"119","author":[{"given":"M.","family":"YOH","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"HONDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1997,8,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268897007541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T12:19:27Z","timestamp":1567426767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268897007541\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,8]]}},"alternative-id":["S0950268897007541"],"URL":"https:\/\/doi.org\/10.1017\/s0950268897007541","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8]]}}}