{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T23:05:43Z","timestamp":1649804743509},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[1997,8,1]],"date-time":"1997-08-01T00:00:00Z","timestamp":870393600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:p>To characterize post-treatment clearance of young forms of \n\n<jats:italic>Plasmodium falciparum<\/jats:italic> from the \n\nblood, three differential equation models, a linear decline, a linear then\n \n\nlogarithmic decline, and \n\nthe Michaelis\u2013Menten (MM) kinetic equation, were fitted to \n\nlog-transformed serial parasite \n\ncounts from 30 semi-immune patients with synchronous parasitaemias \n\nallocated one of six \n\nantimalarial drug regimens. The first two equations were solved analytically.\n \n\nThe MM equation \n\nwas solved numerically using a fifth-order Runge\u2013Kutta method. For\n each \n\nequation, parasite \n\nclearance was assumed stochastic and log-transformed parasite counts \n\nwere assumed to be \n\nnormally distributed at each time-point. Comparisons between models \n\nwere by Minimum \n\nAkaike Information Criterion Estimate. A constrained MM equation fitted\n \n\nthe data at least as \n\nwell as the other two models in 5 of 6 drug groups and also when \n\npooled data were analysed, \n\nproviding a single index which could be used in drug efficacy studies \n\nin similar situations or as \n\npart of more complex models that encompass asynchronous, complicated \n\ninfections.<\/jats:p>","DOI":"10.1017\/s0950268897007693","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:23:42Z","timestamp":1027761822000},"page":"61-69","source":"Crossref","is-referenced-by-count":8,"title":["Clearance of young parasite forms following treatment of \n\nfalciparum malaria in humans: comparison of three simple \n\nmathematical models"],"prefix":"10.1017","volume":"119","author":[{"given":"T. M. E.","family":"DAVIS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. B.","family":"MARTIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1997,8,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268897007693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T12:19:30Z","timestamp":1567426770000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268897007693\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,8]]}},"alternative-id":["S0950268897007693"],"URL":"https:\/\/doi.org\/10.1017\/s0950268897007693","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8]]}}}