{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:09:55Z","timestamp":1761127795777},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1997,10]]},"abstract":"<jats:p>The aim of this study, carried out in 1993, was to evaluate diphtheria\n \n\nimmunity in Siena. \n\nDiphtheria antitoxin levels were measured by means of the immunoenzymatic\n \n\ntest (ELISA) in \n\nserum samples of 602 apparently healthy subjects (239 males and 363 females)\n \n\nof all ages \n\nresiding in Siena. According to widely used criteria, 6% of the total population\n were \n\nsusceptible to diphtheria (antibody levels &lt;0\u00b701 IU\/ml),\n \n\n71% had basic protection \n\n(0\u00b701\u20130\u00b709 IU\/ml) and 23% were fully protected\n \n\n([ges     ]0\u00b71 IU\/ml). The results suggested that a \n\nhigh proportion of young population had a protective level of immunity\n against \n\ndiphtheria, that susceptibility increased with age and a smaller proportion\n of males \n\n(2\u00b79%) than females \n\n(8\u00b73%) were unprotected; this difference was statistically significant.\n \n\nOur results suggest that it \n\nmay be useful to revaccinate adults with low levels of diphtheria toxoid\n so \n\nthat the percentage \n\nthat remains unprotected does not put the community at risk of an outbreak\n \n\nof diphtheria.<\/jats:p>","DOI":"10.1017\/s0950268897007966","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:23:42Z","timestamp":1027761822000},"page":"203-208","source":"Crossref","is-referenced-by-count":8,"title":["Immunity to diphtheria in Siena"],"prefix":"10.1017","volume":"119","author":[{"given":"R.","family":"GASPARINI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"POZZI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"FRAGAPANE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"SEVERINI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"CELLESI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"FABRIZI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"PROVVEDI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"BERGAMINI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1997,10,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268897007966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T16:07:55Z","timestamp":1557590875000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268897007966\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["S0950268897007966"],"URL":"https:\/\/doi.org\/10.1017\/s0950268897007966","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]}}}