{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:11:58Z","timestamp":1793578318703,"version":"4.5.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:p>A multiethnic cohort of adult members of the Kaiser Permanente\n Medical Care Program \n(55300 men and 65271 women) was followed for 15 years (1979\u201393) to\n assess the association \nbetween total cholesterol and risk of infections (other than respiratory\n and HIV) diagnosed in \nthe in-patient setting. Using multivariate Cox regression, total cholesterol\n was inversely and \nsignificantly related to urinary tract, venereal, musculo-skeletal, and\n all infections among men; \nand to urinary tract, all genito-urinary, septicaemia or bacteraemia, miscellaneous\n viral site \nunspecified, and all infections among women. The reduction of risk of all\n infections associated \nwith a 1 <jats:sc>s.d.<\/jats:sc> increase in total cholesterol was \n8% in both men (95% CI, 4\u201312%) and women \n(95% CI, 5\u201311%). For urinary tract infections among men, as for septicaemia\n or bacteraemia \nand nervous system infections among women, the risk relation was restricted\n to persons aged \n55\u201389 years. Nervous system infections were positively related to\n total cholesterol among \nwomen aged 25\u201354. In both genders, the significant inverse association\n with all infections \npersisted after excluding the first 5 years of follow-up. Collectively,\n \nthese data are suggestive of \nan inverse association, although not entirely consistent, between \ntotal cholesterol and incidence \nof infections either requiring hospitalization or acquired in the hospital.\n Further research is \nneeded to elucidate whether these associations are biologically plausible\n or represent \nuncontrolled confounding by unmeasured risk factors.<\/jats:p>","DOI":"10.1017\/s0950268898001435","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:23:42Z","timestamp":1027776222000},"page":"335-347","source":"Crossref","is-referenced-by-count":71,"title":["Cohort study of serum total cholesterol and in-hospital \nincidence of infectious diseases"],"prefix":"10.1017","volume":"121","author":[{"given":"C.","family":"IRIBARREN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. R.","family":"JACOBS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"SIDNEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"CLAXTON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. R.","family":"FEINGOLD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1998,10,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268898001435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T20:12:14Z","timestamp":1557519134000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268898001435\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["S0950268898001435"],"URL":"https:\/\/doi.org\/10.1017\/s0950268898001435","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}