{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:31:02Z","timestamp":1791174662231,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1998,12]]},"abstract":"<jats:p>The <jats:italic>Escherichia coli<\/jats:italic> flora of infants in developed countries\n is dominated by one or a few \nstrains which persist for prolonged periods of time, but no longitudinal\n studies have been \nperformed in developing countries. To this end, we studied the rectal enterobacterial\n flora in 22 \nhome-delivered Pakistani infants during their first 6 months of life. Three\n colonies were \nisolated and species typed on each of 11 sampling occasions. <jats:italic>E. coli<\/jats:italic>\n isolates were strain typed \nusing electromorphic typing of cytoplasmic enzymes, and their O serogroups\n were determined. \nThere was a very rapid turnover of enterobacterial strains in the rectal\n flora of individual \ninfants. On average, 8\u00b75 different <jats:italic>E. coli<\/jats:italic> strains were\n found per infant, and several biotypes of \nother enterobacteria. Less than 50% of the infants were colonized with\n <jats:italic>E. coli<\/jats:italic> from their \nmothers, but strains of maternal origin were four times more likely to\n persists in the infants' \nflora than other <jats:italic>E. coli<\/jats:italic> strains. Enterobacteria other than <jats:italic>E.\n coli<\/jats:italic> were always of non-maternal \norigin, and <jats:italic>Enterobacter cloacae<\/jats:italic> and <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n biotypes recovered from \ncontaminated feeds were later identified in the infants' rectal flora.\n An early colonization with \nklebsiella or enterobacter was significantly associated with diarrhoea\n during the neonatal \nperiod, although these bacteria were not likely to be the cause of the\n disease. The results \nsuggest that poor hygienic conditions result in an unstable and diverse\n enterobacterial flora, \nwhich may influence infant health.<\/jats:p>","DOI":"10.1017\/s0950268898001484","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:23:42Z","timestamp":1027776222000},"page":"587-598","source":"Crossref","is-referenced-by-count":74,"title":["High turnover rate of <i>Escherichia coli<\/i> strains in the intestinal\n \nflora of infants in Pakistan"],"prefix":"10.1017","volume":"121","author":[{"given":"I.","family":"ADLERBERTH","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"JALIL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"CARLSSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"MELLANDER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. \u00c5.","family":"HANSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"LARSSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"KHALIL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E.","family":"WOLD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1998,12,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268898001484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T19:49:12Z","timestamp":1557517752000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268898001484\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,12]]}},"alternative-id":["S0950268898001484"],"URL":"https:\/\/doi.org\/10.1017\/s0950268898001484","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,12]]}}}