{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T22:14:10Z","timestamp":1766441650186},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1999,2]]},"abstract":"<jats:p>Aboriginal communities in Northern Australia with high rates of\n group A streptococcal (GAS) \nskin infection in childhood also have high rates of renal failure in adult\n life. In a cross-sectional study of one such high risk community, albuminuria was used as\n a marker of renal \ndisease. The prevalence of albuminuria increased from 0\/52 in subjects\n aged 10\u201319 years to \n10\/29 (32\u00b79%) in those aged 50 or more (<jats:italic>P<\/jats:italic>&lt;0\u00b7001).\n Antibodies to streptococcal M protein, \nmarkers of past GAS infection, were present in 48\/52 (92%) at ages\n 10\u201319 years, 16\/32 (50%) \nat ages 30\u201339, and 20\/29 (69%) in those aged 50 or more. After\n allowing for the age-dependencies of albuminuria and of M protein antibodies (<jats:italic>P<\/jats:italic>&lt;0\u00b7001)\n albuminuria was \nsignificantly associated with M protein antibodies (<jats:italic>P<\/jats:italic>&lt;0\u00b701).\n Thus, 72% of adults aged 30 or \nmore with M protein antibodies also had albuminuria, compared with only\n 21% of those who \nwere seronegative. More detailed modelling suggested that although most\n Aboriginal people in \nthis community developed M protein antibodies following GAS infection in\n childhood, the \ndevelopment of proteinuria was associated with the persistence of such\n seropositivity into adult \nlife. The models predicted that proteinuria developed at a mean age of\n 30 years in seropositive \npersons, at 45 years in seronegative persons who were overweight, and at\n 62 years in \nseronegative persons of normal weight. We demonstrated a clear association\n between evidence \nof childhood GAS infection and individual risk of proteinuria in adult\n life. This study provided \na strong rationale for prevention of renal disease through the more effective\n control of GAS \nskin infections in childhood and through the prevention of obesity in adult\n life.<\/jats:p>","DOI":"10.1017\/s0950268898001812","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:23:42Z","timestamp":1027776222000},"page":"67-75","source":"Crossref","is-referenced-by-count":16,"title":["Proteinuria is associated with persistence of antibody to \nstreptococcal M protein in Aboriginal Australians"],"prefix":"10.1017","volume":"122","author":[{"given":"A. M.","family":"GOODFELLOW","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. E.","family":"HOY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. S.","family":"SRIPRAKASH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"DALY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"REEVE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"MATHEWS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,2,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268898001812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T20:18:05Z","timestamp":1554668285000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268898001812\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,2]]}},"alternative-id":["S0950268898001812"],"URL":"https:\/\/doi.org\/10.1017\/s0950268898001812","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,2]]}}}