{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T10:04:49Z","timestamp":1655978689242},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[1998,6,1]],"date-time":"1998-06-01T00:00:00Z","timestamp":896659200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1998,6]]},"abstract":"<jats:p>Certain strains of verotoxigenic <jats:italic>Escherichia coli<\/jats:italic> \n(VTEC), and in particular those belonging to \nserogroup O157, cause attaching and effacing (AE) lesions of the host gut\n mucosa during \npathogenesis. The mechanisms involved with bacterial attachment and the\n destruction of \nmicrovilli are determined by a cluster of genes within the LEE region,\n which also encode five \nsecreted proteins. Sera from patients with antibodies to the \nlipopolysaccharide (LPS) of <jats:italic>E. coli<\/jats:italic> \nO157 and other VTEC were tested for antibodies to these secreted proteins.\n Twenty-one of 34 \n(62%) sera with antibodies to the lipopolysaccharide (LPS) of \n<jats:italic>E. coli<\/jats:italic> O157 also contained \nantibodies to one or more of the secreted proteins. Five of 12 sera containing\n antibodies to the \nLPS of a range of other VTEC serogroups also contained antibodies to 1\n or more of the 5 \nsecreted proteins, as did 16 of 70 (23%) sera from patients with haemolytic\n uraemic syndrome \n(HUS), haemorrhagic colitis (HC) or diarrhoea, but without bacteriological\n evidence of \ninfection with VTEC and which did not contain antibodies to VTEC serogroups\n O5, O115, \nO145, O153 or O157. The detection of serum antibodies to secreted proteins\n may provide \nadditional information for interpreting the results of established lipopolysaccharide-based\n \nVTEC serology.<\/jats:p>","DOI":"10.1017\/s0950268898008723","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:23:42Z","timestamp":1027776222000},"page":"239-243","source":"Crossref","is-referenced-by-count":10,"title":["Serum antibodies to secreted proteins in patients infected with \n<i>Escherichia coli<\/i> O157 and other VTEC"],"prefix":"10.1017","volume":"120","author":[{"given":"H.","family":"CHART","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"JENKINS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. R.","family":"SMITH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"ROWE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1998,6,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268898008723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T21:04:55Z","timestamp":1554239095000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268898008723\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,6]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,6]]}},"alternative-id":["S0950268898008723"],"URL":"https:\/\/doi.org\/10.1017\/s0950268898008723","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,6]]}}}