{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:09:33Z","timestamp":1761127773956},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1998,8]]},"abstract":"<jats:p>Changes in the frequency of serogroup B non serotypable \n(B[ratio   ]NT) meningococci isolated in \nEngland and Wales were investigated by T-track fingerprint analysis, DNA\n nucleotide sequence \ndetermination, and serotyping by whole cell ELISA and dot blot assay. Seventy-three\n per cent \nof the isolates designated as B[ratio   ]NT by the Meningococcal Reference\n Unit (MRU) dot blot \nassay during 1993\u20134, expressed variants of the serotyping antigen,\n PorB, that were serotype 4 \nby whole cell ELISA. T-track fingerprint patterns of these and other \u2018serotype\n 4\u2019 isolates \nrevealed five distinct <jats:italic>porB<\/jats:italic> alleles which were shown by nucleotide\n sequence determination to \nencode different peptide sequences. Differential binding of the \u2018serotype\n 4\u2019 mAbs MN14G21 \nand 5DC4C8G8 in whole cell ELISA and dot blot assays was the result, (i)\n of differences in \nthe peptide sequence of predicted surface loop I and (ii) an amino acid\n deletion in predicted \nloop VI of the PorB protein.<\/jats:p>","DOI":"10.1017\/s0950268898008942","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:23:42Z","timestamp":1027776222000},"page":"95-101","source":"Crossref","is-referenced-by-count":19,"title":["Molecular variation of meningococcal serotype 4 antigen genes"],"prefix":"10.1017","volume":"121","author":[{"given":"R.","family":"URWIN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. M.","family":"FEAVERS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"JONES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C. J.","family":"MAIDEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"FOX","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1998,8,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268898008942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T18:51:15Z","timestamp":1554403875000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268898008942\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,8]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,8]]}},"alternative-id":["S0950268898008942"],"URL":"https:\/\/doi.org\/10.1017\/s0950268898008942","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,8]]}}}