{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:34:09Z","timestamp":1762864449105},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[1998,8,1]],"date-time":"1998-08-01T00:00:00Z","timestamp":901929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1998,8]]},"abstract":"<jats:p>Shigellosis is common among children in the Andaman and Nicobar\n islands. Our experience \nshowed two distinct features of shigellosis within a span of 3 years in\n 1994\u20136: (i) changing \npatterns of serotype or subtype specific shigellosis and (ii) emergence\n of multidrug resistant \nisolates with changing R-patterns. The rate of isolation was 10\u00b74\u201327\u00b79%\n with the rate of \nisolation of <jats:italic>Shigella flexneri<\/jats:italic> interchanging with \n<jats:italic>S. dysenteriae<\/jats:italic> alternately. In 1994, <jats:italic>S. flexneri<\/jats:italic> \nsuperseded <jats:italic>S. dysenteriae<\/jats:italic> (48\u00b76% vs. 33\u00b73%; <jats:italic>P<\/jats:italic>&lt;0\u00b705)\n \nwhile <jats:italic>S. dysenteriae<\/jats:italic> dominated over <jats:italic>S. \nflexneri<\/jats:italic> in 1995 (54\u00b77% vs. 34\u00b70%; <jats:italic>P<\/jats:italic>&lt;0\u00b705).\n \nThe picture reversed again in 1996 (63\u00b70% vs. \n22\u00b72%; <jats:italic>P<\/jats:italic>&lt;0\u00b705). Among shigellae isolates, the\n commonest \nserotypes were <jats:italic>S. dysenteriae<\/jats:italic> type \n1 and <jats:italic>S. flexneri<\/jats:italic> type 2a. Isolated shigellae were of multidrug\n resistant type. Seven R-patterns \nwere observed in 1994, while 8R-patterns were observed during the next\n year with the \nemergence of nalidixic acid resistance. In 1996, emergence of gentamicin\n resistance was also \nobserved. All isolates were resistant to ampicillin and sensitive to quinolones.\n The MIC of \nnalidixic acid and gentamicin are [egs     ]128 \u03bcg\/ml and [egs     ]64 \u03bcg\/ml\n \nrespectively. These changing \ntrends in shigellosis has important public health significance.<\/jats:p>","DOI":"10.1017\/s0950268898008978","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:23:42Z","timestamp":1027761822000},"page":"43-48","source":"Crossref","is-referenced-by-count":10,"title":["Shigella infections among children in Andaman \u2013 an \narchipelago of tropical islands in Bay of Bengal"],"prefix":"10.1017","volume":"121","author":[{"given":"A. R.","family":"GHOSH","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C.","family":"SEHGAL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1998,8,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268898008978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T14:51:30Z","timestamp":1554389490000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268898008978\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,8]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,8]]}},"alternative-id":["S0950268898008978"],"URL":"https:\/\/doi.org\/10.1017\/s0950268898008978","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,8]]}}}