{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:30:38Z","timestamp":1780698638812,"version":"3.54.1"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[1999,6,1]],"date-time":"1999-06-01T00:00:00Z","timestamp":928195200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:p>Haemorrhagic fever with renal syndrome (HFRS) is a human disease characterized by flu-like \nsymptoms, renal dysfunction, and in severe cases, haemorrhagic manifestations. The causative \nagents of HFRS are Hantaan (HTN), Seoul (SEO), Puumala (PUU) and Dobrava (DOB) \nhantaviruses. Hantavirus infections are of increasing importance in Europe. Outbreaks occur in \nBelgium with a 3- to 4-year interval with an increasing number of cases. We describe the \nlargest outbreak so far in Belgium with 217 serologically and clinically confirmed cases in the \nperiod between October 1995 and December 1996. We demonstrated that the use of viral \nantigen derived from a local PUU-strain was able to detect significantly more sera positive for \nIgM in an immunofluorescence assay. Furthermore, although in some cases SEO, HTN and \nDOB antibody-reactivities were detected by ELISA, only PUU infections could be confirmed \nby neutralization test. The presence of an unknown hantavirus serotype circulating in Belgium \nshould be considered.<\/jats:p>","DOI":"10.1017\/s0950268899002344","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:23:42Z","timestamp":1027761822000},"page":"447-453","source":"Crossref","is-referenced-by-count":31,"title":["A major outbreak of hantavirus infection in Belgium in 1995 \nand 1996"],"prefix":"10.1017","volume":"122","author":[{"given":"P.","family":"HEYMAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"VERVOORT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"COLSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-K.","family":"CHU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"AVSIC-ZUPANC","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5.","family":"LUNDKVIST","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1999,6,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268899002344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T15:27:50Z","timestamp":1554564470000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268899002344\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,6]]}},"alternative-id":["S0950268899002344"],"URL":"https:\/\/doi.org\/10.1017\/s0950268899002344","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,6]]}}}