{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:03:28Z","timestamp":1790233408522,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[1999,8,1]],"date-time":"1999-08-01T00:00:00Z","timestamp":933465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1999,8]]},"abstract":"<jats:p>The utility of phage typing, pulsed-field gel electrophoresis (PFGE), and plasmid profile \nanalysis was compared, to differentiate between Canadian <jats:italic>Escherichia coli<\/jats:italic> O157[ratio   ]H7 strains of \nhuman (<jats:italic>n<\/jats:italic> = 27) and cattle (<jats:italic>n<\/jats:italic> = 24) origin. The diversity indices for phage typing, plasmid \nanalysis and PFGE were 0\u00b785, 0\u00b769 and 0\u00b793, respectively. PFGE and phage typing were also \napplied to study the role of direct transmission of <jats:italic>E. coli<\/jats:italic> O157[ratio   ]H7 from cattle to humans on \nisolates collected from two separate farm outbreaks. PFGE showed that more than one <jats:italic>E. coli<\/jats:italic> \nO157[ratio   ]H7 strain with varying PFGE DNA subtype profiles, may be responsible for an \noutbreak, and that more than one <jats:italic>E. coli<\/jats:italic> O157[ratio   ]H7 subtype may be circulating on a particular \nfarm at any one time. To our knowledge, this is one of the first reports where PFGE typing \nwas used to verify the direct transmission of <jats:italic>E. coli<\/jats:italic> O157[ratio   ]H7 from cattle to humans.<\/jats:p>","DOI":"10.1017\/s0950268899002551","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:23:42Z","timestamp":1027776222000},"page":"17-24","source":"Crossref","is-referenced-by-count":29,"title":["Molecular typing methods to investigate transmission of \n<i>Escherichia coli<\/i> O157[ratio   ]H7 from cattle to humans"],"prefix":"10.1017","volume":"123","author":[{"given":"M.","family":"LOUIE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"READ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"LOUIE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"ZIEBELL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"RAHN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"BORCZYK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"LIOR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1999,8,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268899002551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T20:51:55Z","timestamp":1554411115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268899002551\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,8]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,8]]}},"alternative-id":["S0950268899002551"],"URL":"https:\/\/doi.org\/10.1017\/s0950268899002551","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,8]]}}}