{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:03:38Z","timestamp":1767909818510,"version":"3.49.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[1999,10,1]],"date-time":"1999-10-01T00:00:00Z","timestamp":938736000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1999,10]]},"abstract":"<jats:p>Bacterial and viral salivary antibody testing is proving sensitive and specific, useful for \nepidemiological studies, and is simple and non-invasive. Salivary serogroup C polysaccharide-specific (SC PS-S) IgA and IgG were determined as a proportion of total salivary IgA and IgG \nin a group of UK infants who were recipients of a conjugated A\/C meningococcal PS vaccine. \nGeometric mean concentrations (GMCs) of salivary SC PS-S IgG per mg of total IgG (\u03bcg\/mg) \nwere 0\u00b71 pre-vaccination, rising to 8\u00b72 post first, 16\u00b71 post second and 29\u00b73 post third dose of \nvaccine. For IgA, the corresponding GMCs in ng\/mg were 0\u00b71, 82\u00b78, 69\u00b76 and 91\u00b72. Significant \ncorrelations (<jats:italic>P<\/jats:italic>&lt;0\u00b70001) were found between serum Ig and salivary IgG SC PS-S antibody for \npre-vaccine and 1 month post each dose of vaccine suggesting that SC PS-S IgG in saliva was \nlargely derived from serum. Of the five infants whose sera were analysed for isotype-specific \nresponses, only traces of IgM and IgA were measurable suggesting that the SC PS-S IgA was \nlocally produced. These findings suggests that the widespread use of meningococcal conjugate \nvaccines is likely to reduce nasopharyngeal carriage and may thereby induce herd immunity in \nthe vaccinated population.<\/jats:p>","DOI":"10.1017\/s0950268899002915","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:23:42Z","timestamp":1027776222000},"page":"201-208","source":"Crossref","is-referenced-by-count":26,"title":["Salivary antibodies following parenteral immunization of \ninfants with a meningococcal serogroup A and C conjugated vaccine"],"prefix":"10.1017","volume":"123","author":[{"given":"R.","family":"BORROW","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"FOX","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"CARTWRIGHT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. T.","family":"BEGG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"JONES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,10,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268899002915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T20:10:50Z","timestamp":1557432650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268899002915\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,10]]}},"alternative-id":["S0950268899002915"],"URL":"https:\/\/doi.org\/10.1017\/s0950268899002915","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,10]]}}}