{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:47:17Z","timestamp":1778654837245,"version":"3.51.4"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:p>In Galicia, Spain, a dramatic increase in the incidence of meningococcal disease was seen in \nthe 1995\u20136. The annual incidence rose to 11 per 10<jats:sup>5<\/jats:sup> inhabitants, and 80% of identified strains \nwere C[ratio   ]2b[ratio   ]P1.2,5. This led to the implementation of an intensive A+C vaccination campaign \nfor the population aged 18 months to 19 years. During this campaign the prevalence of \ncarriage in areas with high and low incidence was studied. Nasopharyngeal swabs were taken \nfrom 9796 subjects immediately before the administration of meningococcal vaccine, plated \nonto Thayer\u2013Martin plates, incubated and sent for analysis to the Reference Laboratory for \n<jats:italic>Neisseria<\/jats:italic> in Spain. The prevalence of the C[ratio   ]2b[ratio   ]P1.2,5 strains was 0\u00b76% (95% CI 0\u00b729\u20130\u00b788) in \nthe high incidence area, and 0\u00b741% (95% CI 0\u00b700\u20131\u00b704) in the low incidence area, and that of \nserogroup C (all strains) 1\u00b736% (95% CI 0\u00b780\u20131\u00b780) and 0\u00b789% (95% CI 0\u00b709\u20131\u00b769) \nrespectively. The prevalence of <jats:italic>N. meningitidis<\/jats:italic> (all strains) was almost the same in both areas \n(8%). Carriers of the epidemic strain were not found in the 2\u20134 year age group, that most \naffected by the disease.<\/jats:p><jats:p>Our data showed a wide distribution but a low carriage rate of the epidemic strain \nC[ratio   ]2b[ratio   ]P1.2,5 in the high and low disease incidence areas studied; the difference in the carriage \nrates between the two areas was not statistically significant.<\/jats:p>","DOI":"10.1017\/s0950268899003027","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:23:42Z","timestamp":1027761822000},"page":"349-357","source":"Crossref","is-referenced-by-count":29,"title":["Carriage of a new epidemic strain of <i>Neisseria meningitidis<\/i> \nand its relationship with the incidence of meningococcal \ndisease in Galicia, Spain"],"prefix":"10.1017","volume":"123","author":[{"given":"S.","family":"FERN\u00c1NDEZ","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"ARREAZA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"SANTIAGO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"MALVAR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"BERR\u00d3N","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"VAZQUEZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"HERVADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"GESTAL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,12,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268899003027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T15:49:23Z","timestamp":1557416963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268899003027\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["S0950268899003027"],"URL":"https:\/\/doi.org\/10.1017\/s0950268899003027","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}