{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:29:02Z","timestamp":1749428942842},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:p>Accuracy assessment of diagnostic tests may be seriously biased if an imperfect reference test is \nused such as parasitology in the diagnosis of visceral leishmaniasis. We compared classical \nvalidity analysis of serological tests for <jats:italic>Leishmania infantum<\/jats:italic> with Latent Class Analysis (LCA), \nto assess whether it circumvented the gold standard problem. Clinical status, three serological \ntests (IFAT, ELISA and DAT) and parasitological data were recorded for 151 dogs captured \nin an endemic area. Sensitivity and specificity estimates from the 2\u00d72 contingency tables were \nbroadly corroborated by LCA, but the latter method provided more precise estimates that were \nrobust for the different fitted models. It furthermore yielded a higher prevalence of infection \nand indicated that parasitology was only 55% sensitive. LCA seems a promising technique for \ntest validation, but caution is required when applying it to sparse data sets. The feasibility and \napplicability of LCA in infectious disease epidemiology is discussed.<\/jats:p>","DOI":"10.1017\/s0950268899003040","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:23:42Z","timestamp":1027776222000},"page":"499-506","source":"Crossref","is-referenced-by-count":33,"title":["The potential of Latent Class Analysis in diagnostic test \nvalidation for canine <i>Leishmania infantum<\/i> infection"],"prefix":"10.1017","volume":"123","author":[{"given":"M.","family":"BOELAERT","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"AOUN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"LIINEV","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"GOETGHEBEUR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"VAN DER STUYFT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,12,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268899003040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T19:49:23Z","timestamp":1557431363000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268899003040\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["S0950268899003040"],"URL":"https:\/\/doi.org\/10.1017\/s0950268899003040","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}