{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:04:05Z","timestamp":1789625045047,"version":"build-2803163510"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:p>We studied the relationship between age and prevalence, duration and incidence of clinical and \nlaboratory evidence of ocular <jats:italic>Chlamydia trachomatis<\/jats:italic> infection in a cohort of Gambian subjects \nexamined bi-weekly for 6 months. The duration of disease and infection, estimated by stratified \nsurvival analysis, proportional hazards regression and Weibull modelling, was markedly age-dependent. The estimated median duration of disease was 13\u00b72 weeks in 0\u20134-year-old subjects \nand 1\u00b77 weeks in those age 15 and over. Adjustment for multiple infections, and for missing \nobservations did not alter this trend. The cumulative incidence rate of disease was reduced \nthreefold with age. More rapid disease resolution is the main source of reduction in prevalence \nof active trachoma and ocular <jats:italic>C. trachomatis<\/jats:italic> infection with age; disease incidence was reduced \nto a lesser extent. This age-dependent resolution may be effected by adaptive cellular immune \nmechanisms. Mechanisms responsible for natural immunity should receive appropriate \nemphasis in vaccine design.<\/jats:p>","DOI":"10.1017\/s0950268899003076","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:23:42Z","timestamp":1027761822000},"page":"479-486","source":"Crossref","is-referenced-by-count":108,"title":["The duration of human ocular <i>Chlamydia trachomatis<\/i> \ninfection is age dependent"],"prefix":"10.1017","volume":"123","author":[{"given":"R.","family":"BAILEY","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"DUONG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"CARPENTER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"WHITTLE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"MABEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1999,12,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268899003076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T15:49:33Z","timestamp":1557416973000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268899003076\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["S0950268899003076"],"URL":"https:\/\/doi.org\/10.1017\/s0950268899003076","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}