{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:55:14Z","timestamp":1787237714780,"version":"build-2736575974"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:p>\n                    To investigate the dynamics of nasopharyngeal colonization with\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    , \nand to determine the prevalent serogroups\/types (SGT) and their antimicrobial susceptibility, \nwe studied 100 infants attending our well-baby clinic. Nasopharyngeal swab specimens were \nobtained at 6, 10, 14, 18 and 22 weeks and at 9 and 18 months of age and submitted for \nculture, serotyping and antimicrobial susceptibility testing of\n                    <jats:italic>S. pneumoniae<\/jats:italic>\n                    . Colonization with \npneumococcus was seen on at least one occasion in 81 infants. The median age of acquisition \nwas 11 weeks and the median duration of carriage was 1\u00b73 months. The common SGTs \nidentified were 6, 19, 14 and 15. SGT 1, which was a common invasive isolate in children in \nour hospital during this period, was not isolated from these children. Sequential colonization \nby 2, 3 or 4 SGTs was observed in 18, 5 and 2 children, respectively. Resistance to penicillin, \nchloramphenicol, cotrimoxazole and erythromycin was observed in 0, 13 (6%) 11 (5%) and \n5 (3%) isolates, respectively. There was a significant difference in susceptibility to \ncotrimoxazole between colonizing and invasive isolates (5% vs. 40%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0\u00b70001).\n                  <\/jats:p>","DOI":"10.1017\/s0950268899003131","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:23:42Z","timestamp":1027761822000},"page":"383-388","source":"Crossref","is-referenced-by-count":36,"title":["Nasopharyngeal colonization of infants in southern India with\n                    <i>Streptococcus pneumoniae<\/i>"],"prefix":"10.1017","volume":"123","author":[{"given":"R.","family":"JEBARAJ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"CHERIAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"RAGHUPATHY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. N.","family":"BRAHMADATHAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. K.","family":"LALITHA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"THOMAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"STEINHOFF","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1999,12,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268899003131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T15:49:27Z","timestamp":1557416967000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268899003131\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["S0950268899003131"],"URL":"https:\/\/doi.org\/10.1017\/s0950268899003131","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}