{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:19:57Z","timestamp":1790698797472,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:p>Mathematical models of transmission dynamics of infectious diseases provide a useful tool for \ninvestigating the impact of community based control measures. Previously, we used a dynamic \n(constant force-of-infection) model for lymphatic filariasis to describe observed patterns of \ninfection and disease in endemic communities. In this paper, we expand the model to examine \nthe effects of control options against filariasis by incorporating the impact of age structure of \nthe human community and by addressing explicitly the dynamics of parasite transmission from \nand to the vector population. This model is tested using data for <jats:italic>Wuchereria bancrofti<\/jats:italic> \ntransmitted by <jats:italic>Culex quinquefasciatus<\/jats:italic> in Pondicherry, South India. The results show that \nchemotherapy has a larger short-term impact than vector control but that the effects of vector \ncontrol can last beyond the treatment period. In addition we compare rates of recrudescence \nfor drugs with different macrofilaricidal effects.<\/jats:p>","DOI":"10.1017\/s0950268899003702","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:23:42Z","timestamp":1027776222000},"page":"529-541","source":"Crossref","is-referenced-by-count":87,"title":["EPIFIL: The development of an age-structured model for \ndescribing the transmission dynamics and control of lymphatic filariasis"],"prefix":"10.1017","volume":"124","author":[{"given":"R. A.","family":"NORMAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"CHAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"SRIVIDYA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. P.","family":"PANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. D.","family":"RAMAIAH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"VANAMAIL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"MICHAEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. K.","family":"DAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A. P.","family":"BUNDY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2000,6,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268899003702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T16:19:44Z","timestamp":1567441184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268899003702\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["S0950268899003702"],"URL":"https:\/\/doi.org\/10.1017\/s0950268899003702","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}