{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:52:57Z","timestamp":1791165177614,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:p>After a primary infection <jats:italic>Coxiella burnetii<\/jats:italic> may persist covertly in animals and recrudesce at \nparturition to be shed in the products of conception and the milk. Similar latent persistence \nand recrudescence occurs in man: namely, infection of placenta, heart valve or mural \nendocardium, bone or liver. The numbers of organisms, their viability and cellular form, and \nthe underlying organ sites of latent infection for the coxiella are obscure. During investigations \nof 29 patients with a chronic sequel to acute Q fever, the post-Q fever fatigue syndrome (QFS) \n[1\u20133], sensitive conventional and TaqMan-based PCR revealed low levels of <jats:italic>C. burnetii<\/jats:italic> DNA \nin blood mononuclear cells (5\/29; 17%), thin needle liver biopsies (2\/14; 14%) and, notably, \nin bone marrow aspirates (13\/20; 65%). Irrespective of the ultimate significance of coxiella \npersistence for QFS, the detection of <jats:italic>C. burnetii<\/jats:italic> genomic DNA in bone marrow several years \nafter a primary infection unveils a new pathological dimension for Q fever.<\/jats:p>","DOI":"10.1017\/s0950268899003763","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:23:42Z","timestamp":1027761822000},"page":"543-549","source":"Crossref","is-referenced-by-count":118,"title":["Long-term persistence of <i>Coxiella burnetii<\/i> in the host after primary Q fever"],"prefix":"10.1017","volume":"124","author":[{"given":"R. J.","family":"HARRIS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"STORM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"LLOYD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"ARENS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. P.","family":"MARMION","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2000,6,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268899003763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T12:19:30Z","timestamp":1567426770000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268899003763\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["S0950268899003763"],"URL":"https:\/\/doi.org\/10.1017\/s0950268899003763","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}