{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T07:09:08Z","timestamp":1769497748131,"version":"3.49.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:p>The induction of immunological memory to serogroup A and C polysaccharides in UK infants \nimmunized with three doses of a meningococcal A\/C oligosaccharide CRM<jats:sub>197<\/jats:sub> conjugate \nvaccine was investigated. Forty UK infants vaccinated previously with three doses of a \nmeningococcal A\/C oligosaccharide-CRM<jats:sub>197<\/jats:sub> conjugate vaccine at 2, 3 and 4 months of age, \nwere revaccinated at a mean age of 145\u00b76 weeks with either a 10 or 50 \u03bcg dose of licensed \nmeningococcal A\/C polysaccharide vaccine. Serogroup-specific antibody and serum bactericidal \nantibody (SBA) responses were measured by enzyme-linked immunosorbent assay and serum \nbactericidal assays, respectively. Following challenge, anti-serogroup A and C polysaccharide \nantibody levels rose from pre-booster geometric mean concentrations (GMC) of 3\u00b71 and 2\u00b71 \n\u03bcg\/ml respectively to 19\u00b76 and 21\u00b70 \u03bcg\/ml 1 month post-booster. Serum bactericidal antibody \ngeometric mean titres (GMTs) for serogroups A and C increased 156- and 113-fold from 2\u00b71 \nand 7\u00b71 pre-booster respectively to 327\u00b74 and 800\u00b77 post-booster. A serogroup A control group \nof 45 children received a 10 \u03bcg dose of licensed meningococcal A\/C polysaccharide vaccine \n(with no prior history of serogroup A vaccination) had serogroup A SBA GMTs of 2\u00b73 pre-\nvaccination rising to 8 post-vaccination with corresponding GMCs of 0\u00b78 and 10\u00b78 \u03bcg\/ml. \nThese rises in SBA following serogroup A\/C conjugate vaccination are indicative of \nimmunological priming.<\/jats:p>","DOI":"10.1017\/s0950268899003787","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:23:42Z","timestamp":1027761822000},"page":"427-432","source":"Crossref","is-referenced-by-count":36,"title":["Induction of immunological memory in UK infants by a meningococcal A\/C conjugate vaccine"],"prefix":"10.1017","volume":"124","author":[{"given":"R.","family":"BORROW","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"FOX","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. C.","family":"RICHMOND","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"CLARK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"SADLER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"FINDLOW","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"MORRIS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. T.","family":"BEGG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. A. V.","family":"CARTWRIGHT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2000,6,1]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268899003787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T12:19:37Z","timestamp":1567426777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268899003787\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["S0950268899003787"],"URL":"https:\/\/doi.org\/10.1017\/s0950268899003787","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}