{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T12:15:38Z","timestamp":1794572138388,"version":"4.9.1"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2000,11,3]],"date-time":"2000-11-03T00:00:00Z","timestamp":973209600000},"content-version":"unspecified","delay-in-days":94,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p>Carriage of <jats:italic>Neisseria lactamica<\/jats:italic> among household contacts of meningococcal disease (MCD) \ncases was investigated during an epidemic in Auckland, New Zealand. The overall carriage rate \nfor <jats:italic>N. lactamica<\/jats:italic> was 10\u00b75% (95% CI 7\u00b74\u201313\u00b75%) \nwith a peak carriage rate in 2-year-olds of 61\u00b75% (95% CI 26\u00b76\u201388\u00b71%). Factors \nassociated with a significant (<jats:italic>P<\/jats:italic> &lt; 0\u00b705) increase in the \nlikelihood of carriage included runny nose, the number of people per bedroom and youth. \nGenetic analysis of isolates revealed a striking correlation of strains within the same household \nbut a high level of diversity between households, suggesting that household contact is an \nimportant factor in acquisition. For household contacts aged less than 5 years, there was a \nhigher rate of carriage amongst those in contact with MCD cases under 8 years old than for \ncontacts of cases aged 8 years and over. It is likely that development of MCD is a reflection of \nthe nature and intensity of the exposure to a virulent strain of <jats:italic>N. meningitidis<\/jats:italic>, coupled with an \nabsence of host resistance among those individuals not carrying <jats:italic>N. lactamica<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s095026889900415x","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:29:39Z","timestamp":1027776579000},"page":"99-104","source":"Crossref","is-referenced-by-count":16,"title":["Carriage of <i>N. lactamica<\/i> in a population at high risk of meningococcal disease"],"prefix":"10.1017","volume":"125","author":[{"given":"G.","family":"SIMMONS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"MARTIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"STEWART","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"BREMNER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2000,11,3]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S095026889900415X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T20:07:09Z","timestamp":1555013229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S095026889900415X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["S095026889900415X"],"URL":"https:\/\/doi.org\/10.1017\/s095026889900415x","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}