{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T20:07:03Z","timestamp":1767125223552},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2000,11,3]],"date-time":"2000-11-03T00:00:00Z","timestamp":973209600000},"content-version":"unspecified","delay-in-days":94,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p>This study evaluated whether a correlation exists between carriage of corynebacteria and the \nlack of immunity to diphtheria toxoid. Samples of both nasal and pharyngeal secretions were \ntaken from 500 apparently healthy subjects of both sexes and of all ages and inoculated onto \nTinsdale's medium. A serum sample was also taken for ELISA test to determine the titre of \ndiphtheria toxin antibodies. None of the subjects carried <jats:italic>Corynebacterium diphtheriae<\/jats:italic>. Ninety-three strains of <jats:italic>Corynebacterium<\/jats:italic> spp. were isolated from 93 subjects and 86 of these were \nclassified to species or group level by biochemical tests. <jats:italic>C. xerosis<\/jats:italic> was the most common \n(25\u00b78%) followed by <jats:italic>C. pseudodiphthericum<\/jats:italic> (16\u00b71%), <jats:italic>C. jeikeium<\/jats:italic> \nand <jats:italic>C. striatum<\/jats:italic> (both 10\u00b78%), \nand <jats:italic>C. urealyticum<\/jats:italic> (9\u00b77%). Three other species accounted for approximately 20% of strains \nand seven were unclassified as biochemically atypical corynebacteria. Non-protective antibodies \nto diphtheria toxin were found in 80 of the 93 subjects and a strong statistical association was \ndemonstrated between carriage of corynebacteria and non-protective levels of anti-toxin \nantibodies. The remaining 13 subjects had protective levels of antitoxin antibodies. In contrast, \nonly 45 of the 407 non-colonized subjects had non-protective antitoxin titres. The prevalence of \ncarriage increased with age among males as did the percentage of non-protected subjects. The \nprevalence of female carriers of corynebacteria was significantly lower. Serum samples from 12 \nsubjects with different antibody titres to diphtheria toxoid reacted to varying degrees with \nwhole-cell lysates of a number of species of corynebacteria. The results suggest that a causal \nrelationship may exist between nasopharyngeal carriage of corynebacteria and a low anti-diphtheria toxin immune response.<\/jats:p>","DOI":"10.1017\/s0950268899004331","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:23:42Z","timestamp":1027761822000},"page":"105-112","source":"Crossref","is-referenced-by-count":25,"title":["Evidence of increased carriage of <i>Corynebacterium<\/i> spp. in \nhealthy individuals with low antibody titres against diphtheria \ntoxoid"],"prefix":"10.1017","volume":"125","author":[{"given":"M.","family":"BERGAMINI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"FABRIZI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"PAGANI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"GRILLI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"SEVERINI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"CONTINI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2000,11,3]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268899004331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T16:07:23Z","timestamp":1554998843000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268899004331\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["S0950268899004331"],"URL":"https:\/\/doi.org\/10.1017\/s0950268899004331","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}