{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:45:32Z","timestamp":1790300732241,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2001,1,2]],"date-time":"2001-01-02T00:00:00Z","timestamp":978393600000},"content-version":"unspecified","delay-in-days":93,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p>A new variant within the electrophoretic type (ET)-37 complex of <jats:italic>Neisseria meningitidis<\/jats:italic>, ET-15, \nfirst detected in Canada in 1986, has been associated with severe clinical infections and high \nmortality rates in several European countries, Israel and Australia. To ascertain the genetic and \nepidemiological relationships of ET-15 strains from different geographical areas, 72 ET-15 \nisolates from 10 countries were compared to 13 isolates representing other clones of the ET-37 \ncomplex. The 85 strains were analysed by pulsed-field gel electrophoresis (PFGE) using 2 \nrestriction endonucleases and Southern hybridization with 10 genetic markers. Four ET-15 \nstrains and 4 other strains of the ET-37 complex were further examined using an additional \nrestriction enzyme and a total of 18 genetic markers. PFGE fingerprints of the ET-15 strains \nwere closely related. Strains within each country were even more closely related, suggesting \nsingle introductions of the clone. Physical mapping of genes in ET-15 and other strains of the \nET-37 complex demonstrated that large genetic rearrangements of the genome have occurred in \nassociation with the appearance of the ET-15 variant.<\/jats:p>","DOI":"10.1017\/s0950268899004471","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:23:42Z","timestamp":1027776222000},"page":"285-298","source":"Crossref","is-referenced-by-count":36,"title":["Genetic characterization of a new variant within the ET-37 \ncomplex of <i>Neisseria meningitidis<\/i> associated with outbreaks \nin various parts of the world"],"prefix":"10.1017","volume":"125","author":[{"given":"J.","family":"JELFS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"MUNRO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. E.","family":"ASHTON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"CAUGANT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2001,1,2]]},"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268899004471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T20:15:33Z","timestamp":1557346533000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268899004471\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["S0950268899004471"],"URL":"https:\/\/doi.org\/10.1017\/s0950268899004471","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}