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Superfusion of the retina with serotonin (25\u2013500 \u03bcM) increased the maintained activity of OFF-center ganglion cells and decreased the maintained activity of ON-center ganglion cells. In addition, serotonin also attenuated the excitatory responses to annular stimuli, suggesting a decrease in the strength of surround input to the ganglion cells. The effects of serotonin on OFF-center ganglion cells were mimicked by the nonselective 5-HT<jats:sub>1<\/jats:sub>, agonist 5-MeOT and the 5-HT<jats:sub>1<\/jats:sub>receptor agonist 8-OH-DPAT, while only 5-MeOT mimicked the action of serotonin on ON-center ganglion cells. The effects of exogenously applied serotonin on the ganglion cells could be blocked by the mixed 5-HT<jats:sub>1<\/jats:sub>\/5-HT<jats:sub>2<\/jats:sub>receptor antagonist methysergide but not by the 5-HT<jats:sub>2<\/jats:sub>receptor antagonist mianserin or the dopamine receptor antagonist haloperidol.<\/jats:p><jats:p>These results support previous anatomical and biochemical evidence that serotonin functions in a neurotransmitter or neuromodulatory role in the teleost retina and suggest that serotonin may be involved in modulating the maintained activity and surround input to the ganglion cells. The results also indicate that two different types of receptors may mediate the actions of serotonin in the ON and OFF pathways, respectively.<\/jats:p>","DOI":"10.1017\/s0952523800010762","type":"journal-article","created":{"date-parts":[[2009,6,2]],"date-time":"2009-06-02T12:01:33Z","timestamp":1243944093000},"page":"353-364","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":11,"title":["Effects of serotonergic agonists and antagonists on ganglion cells in the goldfish retina"],"prefix":"10.48130","volume":"9","author":[{"given":"Steven H.","family":"Hensley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel L.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27968","published-online":{"date-parts":[[2009,6,2]]},"reference":[{"key":"S0952523800010762_ref001","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800005915"},{"key":"S0952523800010762_ref009","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0022-3565(25)24854-6","article-title":"Characterization of the 5-hydroxy-tryptamine1A receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity of guinea pig and rat hippocampal membranes","volume":"238","author":"Devivo","year":"1986","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"S0952523800010762_ref057","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.73.3.265"},{"key":"S0952523800010762_ref052","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015266"},{"key":"S0952523800010762_ref013","doi-asserted-by":"publisher","DOI":"10.1007\/BF00220821"},{"key":"S0952523800010762_ref016","doi-asserted-by":"publisher","DOI":"10.1139\/y90-085"},{"key":"S0952523800010762_ref015","doi-asserted-by":"publisher","DOI":"10.1021\/jm00384a001"},{"key":"S0952523800010762_ref021","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90658-2"},{"key":"S0952523800010762_ref044","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1989.tb14630.x"},{"key":"S0952523800010762_ref039","first-page":"107","volume-title":"Retinal Neurotransmitters and Modulators: Models for the Brain","author":"Redburn","year":"1985"},{"key":"S0952523800010762_ref022","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800000894"},{"key":"S0952523800010762_ref025","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(83)90194-3"},{"key":"S0952523800010762_ref024","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(81)90027-4"},{"key":"S0952523800010762_ref020","doi-asserted-by":"publisher","DOI":"10.3109\/10799898809048978"},{"key":"S0952523800010762_ref040","first-page":"265","volume-title":"Serotonin \u2014 From Cell Biology to Pharmacology and Therapeutics","author":"Richardson","year":"1990"},{"key":"S0952523800010762_ref054","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.12.7825"},{"key":"S0952523800010762_ref029","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-09-03427.1988"},{"key":"S0952523800010762_ref014","doi-asserted-by":"publisher","DOI":"10.1126\/science.73223"},{"key":"S0952523800010762_ref056","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1981.tb01628.x"},{"key":"S0952523800010762_ref026","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1982.tb03971.x"},{"key":"S0952523800010762_ref042","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.3.11.2673898"},{"key":"S0952523800010762_ref032","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.67.6.661"},{"key":"S0952523800010762_ref041","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1988.60.5.1549"},{"key":"S0952523800010762_ref002","doi-asserted-by":"publisher","DOI":"10.1021\/jm00140a002"},{"key":"S0952523800010762_ref012","first-page":"880","article-title":"A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system","volume":"34","author":"Dumuis","year":"1989","journal-title":"Molecular Pharmacology"},{"key":"S0952523800010762_ref051","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012295"},{"key":"S0952523800010762_ref047","first-page":"137","volume-title":"Bioelectric Recording Techniques, Part A. 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