{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:18:53Z","timestamp":1759033133730,"version":"3.37.0"},"reference-count":24,"publisher":"Maximum Academic Press","issue":"5","license":[{"start":{"date-parts":[[2009,6,2]],"date-time":"2009-06-02T00:00:00Z","timestamp":1243900800000},"content-version":"unspecified","delay-in-days":4292,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Vis Neurosci"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The GABA<jats:sub>C<\/jats:sub>receptor subtypes on bipolar cells of rats and cold-blooded vertebrates differ in their pharmacological properties and probably have different molecular compositions. With the exception of the rat, native GABA<jats:sub>C<\/jats:sub>receptors in mammals had not been studied. In ferret, whole-cell, voltage-clamp recordings were made from bipolar cells in the retinal slice preparation to determine which subtype of GABA<jats:sub>C<\/jats:sub>receptor predominated. Puff-evoked GABA currents in bipolar cells were partially reduced by the GABA<jats:sub>A<\/jats:sub>receptor antagonist bicuculline, indicating that both GABA<jats:sub>A<\/jats:sub>and GABA<jats:sub>C<\/jats:sub>receptors mediated the responses. By contrast, GABA currents of ganglion cells were always completely blocked by bicuculline, indicating that GABA<jats:sub>A<\/jats:sub>receptors predominated on these cells. Small-amplitude GABA currents of bipolar cells evoked by short-duration puffs were less sensitive to bicuculline than large-amplitude currents evoked by long-duration puffs. This indicates that GABAc receptors mediated proportionately more of the small-amplitude, puff-evoked responses and GABA<jats:sub>A<\/jats:sub>receptors mediated more of the large-amplitude, puff-evoked responses. In bipolar cells, the bicuculline-resistant component of the GABA current was entirely blocked by 3-APMPA (3-aminopropyl-(methyl)phosphonic acid), a GABA<jats:sub>C<\/jats:sub>receptor antagonist. Picrotoxin, which is relatively ineffective at rat GABA<jats:sub>C<\/jats:sub>receptors, completely blocked GABA currents in ferret bipolar cells, indicating that GABA<jats:sub>C<\/jats:sub>receptors on ferret bipolar cells resemble those in lower vertebrates rather than those in the rat retina. These results suggest that there may be a diversity of GABAc receptor subtypes on mammalian bipolar cells.<\/jats:p>","DOI":"10.1017\/s095252380001169x","type":"journal-article","created":{"date-parts":[[2009,6,2]],"date-time":"2009-06-02T11:12:33Z","timestamp":1243941153000},"page":"989-994","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":34,"title":["GABA<sub>C<\/sub>receptors on ferret retinal bipolar cells: A diversity of subtypes in mammals?"],"prefix":"10.48130","volume":"14","author":[{"given":"Peter D.","family":"Lukasiewicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel O.L.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27968","published-online":{"date-parts":[[2009,6,2]]},"reference":[{"key":"S095252380001169X_ref024","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.25.11756"},{"key":"S095252380001169X_ref023","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800007525"},{"key":"S095252380001169X_ref020","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.25.11751"},{"key":"S095252380001169X_ref018","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.74.5.1920"},{"key":"S095252380001169X_ref017","doi-asserted-by":"publisher","DOI":"10.1038\/361162a0"},{"key":"S095252380001169X_ref015","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-04-02668.1995"},{"key":"S095252380001169X_ref013","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-03-01079.1994"},{"key":"S095252380001169X_ref012","first-page":"1201","article-title":"A novel GABA receptor on bipolar cell terminals in the tiger salamander retina","volume":"14","author":"Lukasiewicz","year":"1994","journal-title":"Journal of Neuroscience"},{"key":"S095252380001169X_ref007","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-14-04479.1996"},{"key":"S095252380001169X_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(92)90312-G"},{"key":"S095252380001169X_ref004","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.7.2673"},{"key":"S095252380001169X_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)98370-E"},{"key":"S095252380001169X_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90787-6"},{"key":"S095252380001169X_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(95)00205-7"},{"key":"S095252380001169X_ref011","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-06-04592.1995"},{"key":"S095252380001169X_ref016","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.10.4318"},{"key":"S095252380001169X_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/BF02755587"},{"key":"S095252380001169X_ref001","first-page":"227","article-title":"Homomeric \u03c1l GABA channels: Activation properties and domains","volume":"2","author":"Amin","year":"1994","journal-title":"Receptors and Channels"},{"key":"S095252380001169X_ref019","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0026-895X(25)09011-X","article-title":"Gamma-aminobutyric acid A or C receptor? 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