{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:01:24Z","timestamp":1792602084592,"version":"4.5.0"},"reference-count":0,"publisher":"Maximum Academic Press","issue":"5","license":[{"start":{"date-parts":[[2000,12,15]],"date-time":"2000-12-15T00:00:00Z","timestamp":976838400000},"content-version":"unspecified","delay-in-days":105,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vis Neurosci"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:p>Retinal horizontal cells display large receptive fields \nas a result of extensive electrical coupling <jats:italic>via<\/jats:italic> \ngap junctions. There is abundant evidence that these gap \njunctions are dynamically regulated by changes in the adaptational \nstate of the retina. The neuromodulator dopamine appears \nto play a major role in regulating gap junctional conductances \nof horizontal cells. Emerging evidence indicates that nitric \noxide (NO) also acts as a neuromodulator in the retina \nand, more specifically, regulates the coupling between \nhorizontal cells. In the present study, we examined the \neffects of a nitric oxide, and its secondary messenger \ncGMP, on electrical and tracer coupling between A-type \nand between B-type horizontal cells in the rabbit retina. \nApplication of the NO donors S-nitroso-N-acetylpenicillamine \n(SNAP) or sodium nitroprusside (SNP) significantly reduced \nthe coupling between horizontal cells as evidenced by a \ndecrease in their space constants, annulus-to-small spot \nresponse ratios, and the extent of tracer coupling following \ninjection with Neurobiotin. Further, application of SNP \neliminated the increase in coupling of horizontal cells \nnormally seen with exposure to dim background illumination. \nApplication of 8-bromo-cGMP produced effects similar to \nthose of the NO donors, consistent with the idea that the \nuncoupling actions of NO were mediated <jats:italic>via<\/jats:italic> a cGMP \ncascade.<\/jats:p>","DOI":"10.1017\/s0952523800175133","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:39:08Z","timestamp":1027777148000},"page":"799-811","source":"Crossref","is-referenced-by-count":44,"title":["Effects of nitric oxide on horizontal cells in the rabbit retina"],"prefix":"10.48130","volume":"17","author":[{"given":"DAIYAN","family":"XIN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEWART A.","family":"BLOOMFIELD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27968","published-online":{"date-parts":[[2000,12,15]]},"container-title":["Visual Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0952523800175133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T20:00:34Z","timestamp":1735848034000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0952523800175133\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0952523800175133"],"URL":"https:\/\/doi.org\/10.1017\/s0952523800175133","relation":{},"ISSN":["0952-5238","1469-8714"],"issn-type":[{"value":"0952-5238","type":"print"},{"value":"1469-8714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}